Cutaneous squamous cell carcinoma developing from recessive dystrophic epidermolysis bullosa: A case report and an immunohistochemical study

Akira Tsukada, Taku Fujimura, Sadanori Furudate, Yumi Kambayashi, Yukikazu Numata, Takahiro Haga, Akira Hashimoto, Setsuya Aiba

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

We describe a 49-year-old Japanese woman with cutaneous squamous cell carcinoma (SCC) developing from recessive dystrophic epidermolysis bullosa (RDEB). Interestingly, immunohistochemical staining revealed dense infiltration of CD163+ M2 macrophages and numerous Foxp3+ regulatory T cells (Tregs) around the tumor. Since the contribution of immunosuppressive factors (e.g. TGFβ) to the carcinogenesis of SCC from RDEB was recently reported, our present findings suggest one of the possible contributions of immunosuppressive cells, such as CD163+ M2 macrophages and Tregs, to the carcinogenesis of SCC from RDEB.

Original languageEnglish
Pages (from-to)197-201
Number of pages5
JournalCase Reports in Dermatology
Volume4
Issue number3
DOIs
Publication statusPublished - 2012 Apr 20

Keywords

  • Carcinogenesis
  • Immunosuppressive cells
  • Recessive dystrophic epidermolysis bullosa
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Dermatology

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