Current usage of diuretics among hypertensive patients in Japan: The Japan home versus office blood pressure measurement evaluation (J-HOME) study

Kayo Murai, Taku Obara, Takayoshi Ohkubo, Hirohito Metoki, Takuya Oikawa, Ryusuke Inoue, Rie Komai, Tsuyoshi Horikawa, Kei Asayama, Masahiro Kikuya, Kazuhito Totsune, Junichiro Hashimoto, Yutaka Imai, Masatoshi Fujishima, Takao Saruta, Toshio Ogihara, Kazuaki Shimamoto, Toshiro Fujita, Kazuyuki Shimada, Iwao KuwajimaSatoru Kuriyama, Kazuomi Kario

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

In the Japan Home versus Office Blood Pressure Measurement Evaluation (J-HOME) study, we examined the current situation with respect to the prescription of diuretics, including the prevalence of diuretic treatment and the dosages used for patients with essential hypertension in primary care settings. Of the 3,400 hypertensive patients included in the study, 315 (9.3%) patients (mean age: 66.9±10.4 years; males: 43.5%) were prescribed diuretics. Compared with patients who were not using diuretics, those who were using diuretics were more obese and had more complications. The most commonly prescribed diuretic among the 331 prescriptions in the 315 diuretic users was trichlormethiazide (44%), followed by indapamide (15%) and spironolactone (14%). Among patients being treated with diuretics, monotherapy was used in only 5% of patients; in the majority of patients combination therapy including diuretics (95%) was used. Relatively low dosages of diuretics were generally used. There was a difference between the actual dosages prescribed and those recommended by the Japanese Society of Hypertension (JSH) guidelines or the product information approved in Japan. Compared with previous estimates of the prevalence of diuretic use in hypertensives in Japan (4.0-5.4%), the rate in the J-HOME study (9.3%) was higher. This may be attributable at least in part to the results of the many published, large-scale intervention trials confirming the clinical significance of diuretics. Although a relatively high dosage is recommended in the diuretic product information and in the JSH guidelines, dosages of diuretics should be reconsidered in Japan.

Original languageEnglish
Pages (from-to)857-863
Number of pages7
JournalHypertension Research
Volume29
Issue number11
DOIs
Publication statusPublished - 2006 Nov

Keywords

  • Diuretics
  • Hypertension
  • Prescribed doses

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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    Murai, K., Obara, T., Ohkubo, T., Metoki, H., Oikawa, T., Inoue, R., Komai, R., Horikawa, T., Asayama, K., Kikuya, M., Totsune, K., Hashimoto, J., Imai, Y., Fujishima, M., Saruta, T., Ogihara, T., Shimamoto, K., Fujita, T., Shimada, K., ... Kario, K. (2006). Current usage of diuretics among hypertensive patients in Japan: The Japan home versus office blood pressure measurement evaluation (J-HOME) study. Hypertension Research, 29(11), 857-863. https://doi.org/10.1291/hypres.29.857