Current studies on a working model of CaM kinase II in hippocampal long-term potentiation and memory

Koji Fukunaga, Eishichi Miyamoto

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

There have been recent advances in understanding the molecular basis of the long-term potentiation (LTP) of synaptic transmission in the hippocampus. This review documents current views on mechanisms underlying LTP induction, from activation of the NMDA receptor to stimulation of Ca2+/calmodulin-dependent protein kinase II (CaM kinase II). We will focus in particular on recent findings of how CaM kinase II encodes the frequency of synaptic usage and serves as a molecular memory switch at the synapse. Furthermore, a role for CaM kinase II in spatial learning and memory is demonstrated by recent studies using transgenic mice.

Original languageEnglish
Pages (from-to)7-15
Number of pages9
JournalJapanese Journal of Pharmacology
Volume79
Issue number1
DOIs
Publication statusPublished - 1999 Jan 1
Externally publishedYes

Keywords

  • Ca/calmodulin-dependent protein kinase II
  • Hippocampus
  • Long-term depression
  • Long-term potentiation
  • Spatial learning

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

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