Current status of 21 patients who have survived more than 20 years since undergoing surgery for biliary atresia

Masaki Nio, Ryoji Ohi, Yutaka Hayashi, Naobumi Endo, Mohamed Ibrahim, Daiji Iwami

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)

Abstract

Between 1952 and 1993, 289 patients with biliary atresis underwent surgery at the authors' institution. Twenty-two of them survived more than 20 years; one has since died of hepatic failure (at age 28 years). Of the 21 current survivors (age range, 20 to 39 years), 13 underwent hepatic portoenterostomy; the others had hepaticoenterostomy. None of these patients has undergone liver transplantation. Sixteen patients have led near-normal lives. This includes three married women, one of whom has given birth to a healthy baby boy. Of the six patients who had portal hypertension, three underwent both splenectomy and proximal splenorenal shunting in or before 1985. None of these patients has required additional treatment for portal hypertension. The quality of life of one patient has been severely affected by an unrelated condition (Turner's syndrome). A 22-year-old man was diagnosed as having intrahepatic stones 3 years ago. In another 22-year-old man, hepatic dysfunction developed after frequent episodes of cholangitis. He is now being considered for liver transplantation. The majority of the long-term survivors have good quality of life. However, a few continue to suffer from complications including recurrent cholangitis. Close long-term postoperative follow-up is required for patients with biliary atresia.

Original languageEnglish
Pages (from-to)381-384
Number of pages4
JournalJournal of Pediatric Surgery
Volume31
Issue number3
DOIs
Publication statusPublished - 1996 Mar

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

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