Current Status and Prospects of Complement-Targeting Therapy for Neuromyelitis Optica

Hiroshi Kuroda, Kazuo Fujihara

Research output: Contribution to journalReview article

Abstract

Neuromyelitis optica (NMO) is clinically characterized by severe optic neuritis and long myelitis; and is associated with aquaporin-4 immunoglobulin-G (AQP4-IgG), an autoantibody directed against aquaporin-4 (AQP4), which is an astrocytic water channel protein. Until recent years, the treatment of NMO has mainly focused on the suppression of lymphocytes and depletion of autoantibodies. However, several studies on the pathogehesis of the disease in human pathology, cultured cells, and animal models have revealed that astrocyte injury in NMO is mainly caused by the complement-dependent cytotoxicity following AQP4-IgG binding to AQP4. Moreover, complement-targeting therapy has recently been translated into practical applications in several hematological disorders. and similary, also in the cases of NMO. In this article, we review the relevance of the complement system in the pathogenesis of NMO. Additionally, we review the current status and prospects of the complement-targeting therapy for NMO, including the clinical trials of eculizumab and C1 inhibitor for NMO, and the experimental studies on C1 inhibition by monoclonal antibodies.

Original languageEnglish
Pages (from-to)573-580
Number of pages8
JournalBrain and nerve = Shinkei kenkyu no shinpo
Volume71
Issue number6
DOIs
Publication statusPublished - 2019 Jun 1

ASJC Scopus subject areas

  • Clinical Neurology

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