Current state of anti-angiogenic therapy

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Angiogenesis is the formation of new vasculature from the pre-existing one. It is a physiological process observed in developing fetus, ovarian follicle, endometrium or wound healing. However, several pathological conditions are involved in persistent angiogenesis: various solid tumors, eye diseases including diabetic retinopathy, rheumatoid arthritis, psoriasis and atherosclerosis. The concept that the growth of solid tumors is angiogenesis dependent was first proposed by Folkman in the early 1970s and is now generally accepted. Moreover, metastasis and the growth of metastatic tumor are found to be tumor angiogenesis dependent. Therefore angiogenesis inhibition has become a novel strategy for cancer treatment. Several angiogenesis inhibitors have been found and characterized. This review summarizes the current state of anti-angiogenic therapy.

Original languageEnglish
Pages (from-to)972-978
Number of pages7
JournalBiotherapy
Volume10
Issue number7
Publication statusPublished - 1996 Jan 1

Keywords

  • Angiogenesis inhibitor
  • Anti-cancer treatment
  • Clinical trial

ASJC Scopus subject areas

  • Cancer Research
  • Immunology and Allergy

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