Current standard treatment for pediatric glioma patients

Yukihiko Sonoda, Toshihiro Kumabe, Ryuta Saito, Masayuki Kanamori, Yoji Yamashita, Teiji Tominaga

Research output: Contribution to journalArticle

Abstract

In this paper, we selected three representative disorders among pediatric gliomas and reviewed standard treatments for these diseases. Optic pathway/hypothalamic astrocytoma: The formation of this rare disease is involved with BRAF mutation as well as cerebellar pilocytic astrocytoma. Radical resection is not recommended as initial therapy due to high morbidity. Despite its good tumor control, radiotherapy is not a standard therapy due to neuroendocrine and neurocognitive dysfunction. Several papers have reported the effectiveness of platinum-based chemotherapy, which is a useful for induction therapy. Ependymal tumors: Recent progress in molecular analyses has suggested that some markers might be used for staging ependymoma. While total resection is considered to be strongly correlated with patients'survival, the majority of recurrence occurs in the primary site. Despite many clinical trials, chemotherapeutic agents were not found to be effective for this disease. Since whole brain radiation cannot prevent dissemination, local radiation is recommended for adjuvant therapy. Brain stem gliomas: The prognosis of this disease is still dismal, and median survival time is within 1 year. Although clinical trials have been conducted to assess the efficacy of chemotherapy prior to, concomitantly with, or after radiotherapy, an effective regimen has not yet been established. Therefore, only conventional local radiotherapy is the standard regimen for this disease. A new therapeutic approach, such as convection-enhanced drug delivery, would be required for improved outcomes in patients with this disease.

Original languageEnglish
Pages (from-to)224-235
Number of pages12
JournalJapanese Journal of Neurosurgery
Volume21
Issue number3
Publication statusPublished - 2012 Mar 20

Keywords

  • Brain stem glioma
  • Ependymal tumor
  • Optic pathway hypothalamic astrocytoma
  • Pediatric glioma

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

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