Curative treatment of Stage I non-small-cell lung cancer with carbon ion beams using a hypofractionated regimen

Tadaaki Miyamoto, Masayuki Baba, Naoyoshi Yamamoto, Masashi Koto, Toshiyuki Sugawara, Tomoyasu Yashiro, Kennoshuke Kadono, Hidefumi Ezawa, Hirohiko Tsujii, Jun Etsu Mizoe, Kyosan Yoshikawa, Susumu Kandatsu, Takehiko Fujisawa

    Research output: Contribution to journalArticlepeer-review

    102 Citations (Scopus)

    Abstract

    Purpose: A phase I/II study on carbon ion radiotherapy for Stage I non-small-cell lung cancer (NSCLC) was first conducted between 1994 and 1999 and determined the optimal dose. Second, a Phase II study using the optimal dose was performed. The purpose of the present study was to clarify the local control and 5-year survival rates. Methods and Materials: Between April 1999 and December 2000, 50 patients with 51 primary lesions were treated. Using a fixed dose of 72 GyE in nine fractions over 3 weeks, the primary tumors were irradiated with carbon ion beams alone. The average age of the patients was 74.5 years. Thirty-three (66%) of these were medically inoperable. Local control and survival were determined by using the Kaplan-Meier method and the data were statistically processed by using the log-rank test. Results: All patients were observed for a minimum of 5 years or until death with a median follow-up time of 59.2 months (range, 6.0-83.0 months). The local control rate for all patients was 94.7%. The patients' 5-year cause-specific survival rate was 75.7% (IA: 89.4; IB: 55.1), and overall survival 50.0% (IA: 55.2; IB: 42.9). No toxic reactions in the lung greater than Grade 3 were detected. Conclusions: Carbon ion radiotherapy, a new treatment modality with superior benefits in terms of quality of life and activity of daily living, has been proven as a valid alternative to surgery for Stage I NSCLC and to offer particular benefits, especially for elderly and inoperable patients.

    Original languageEnglish
    Pages (from-to)750-758
    Number of pages9
    JournalInternational Journal of Radiation Oncology Biology Physics
    Volume67
    Issue number3
    DOIs
    Publication statusPublished - 2007 Mar 1

    Keywords

    • Carbon ion beams
    • Heavy particles
    • Hypofraction
    • Non-small-cell lung cancer
    • Stage I

    ASJC Scopus subject areas

    • Radiation
    • Oncology
    • Radiology Nuclear Medicine and imaging
    • Cancer Research

    Fingerprint Dive into the research topics of 'Curative treatment of Stage I non-small-cell lung cancer with carbon ion beams using a hypofractionated regimen'. Together they form a unique fingerprint.

    Cite this