Csrp1 regulates dynamic cell movements of the mesendoderm and cardiac mesoderm through interactions with Dishevelled and Diversin

Kota Y. Miyasaka, Yasuyuki S. Kida, Takayuki Sato, Mari Minami, Toshihiko Ogura

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

Zebrafish Csrp1 is a member of the cysteine- and glycine-rich protein (CSRP) family and is expressed in the mesendoderm and its derivatives. Csrp1 interacts with Dishevelled 2 (Dvl2) and Diversin (Div), which control cell morphology and other dynamic cell behaviors via the noncanonical Wnt and JNK pathways. When csrp1 message is knocked down, abnormal convergent extension cell movement is induced, resulting in severe deformities in midline structures. In addition, cardiac bifida is induced as a consequence of defects in cardiac mesoderm cell migration. Our data highlight Csrp1 as a key molecule of the noncanonical Wnt pathway, which orchestrates cell behaviors during dynamic morphogenetic movements of tissues and organs.

Original languageEnglish
Pages (from-to)11274-11279
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume104
Issue number27
DOIs
Publication statusPublished - 2007 Jul 3
Externally publishedYes

Keywords

  • Gastrulation
  • Heart
  • Wnt
  • Zebrafish

ASJC Scopus subject areas

  • General

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