CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects

K. Buerger, S. J. Teipel, Ray Zinkowski, K. Blennow, H. Arai, R. Engel, K. Hofmann-Kiefer, C. McCulloch, U. Ptok, R. Heun, N. Andreasen, J. DeBernardis, D. Kerkman, H. J. Moeller, P. Davies, H. Hampel

Research output: Contribution to journalArticlepeer-review

197 Citations (Scopus)

Abstract

In this longitudinal study of 77 patients with mild cognitive impairment (MCI), the authors analyzed whether levels of tau protein phosphorylated at threonine 231 (p-tau231) in CSF correlate with progression of cognitive decline. High CSF p-tau231 levels at baseline, but not total tau protein levels, correlated with cognitive decline and conversion from MCI to AD. Independently, old age and APOE-ε4 carrier status were predictive as well. Our data indicate that an increased p-tau231 level is a potential risk factor for cognitive decline in patients with MCI.

Original languageEnglish
Pages (from-to)627-629
Number of pages3
JournalNeurology
Volume59
Issue number4
DOIs
Publication statusPublished - 2002 Aug 27
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

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