In this longitudinal study of 77 patients with mild cognitive impairment (MCI), the authors analyzed whether levels of tau protein phosphorylated at threonine 231 (p-tau231) in CSF correlate with progression of cognitive decline. High CSF p-tau231 levels at baseline, but not total tau protein levels, correlated with cognitive decline and conversion from MCI to AD. Independently, old age and APOE-ε4 carrier status were predictive as well. Our data indicate that an increased p-tau231 level is a potential risk factor for cognitive decline in patients with MCI.
ASJC Scopus subject areas
- Clinical Neurology