CSF-chemokines in HTLV-I-associated myelopathy: CXCL10 up-regulation and therapeutic effect of interferon-α

Koichi Narikawa, Kazuo Fujihara, Tatsuro Misu, Juan Feng, Juichi Fujimori, Ichiro Nakashima, Isabelle Miyazawa, Hiroshi Saito, Shigeru Sato, Yasuto Itoyama

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

We measured four chemokines in the cerebrospinal fluid (CSF) in human T-lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) with ELISA. CXCL10/IP-10, a T cell type 1 (Th1)-associated chemokine, was significantly elevated in HAM/TSP compared with controls, and the values were even significantly higher in HAM/TSP than in multiple sclerosis (MS) in which CXCL10/IP-10 up-regulation was previously reported. Among Th2-associated chemokines, CCL17/TARC and CCL11/Eotaxin in HAM/TSP were not different from those in controls. As shown in MS, CCL2/MCP-1 was significantly lower in HAM/TSP than in control. Following interferon (IFN)-α therapy in HAM/TSP, CCL2/MCP-1 became significantly higher than that before therapy, which may reflect a Th2 induction, while CXCL10/IP-10 remained elevated.

Original languageEnglish
Pages (from-to)177-182
Number of pages6
JournalJournal of Neuroimmunology
Volume159
Issue number1-2
DOIs
Publication statusPublished - 2005 Feb

Keywords

  • Chemokine
  • Human T-lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis
  • Multiple sclerosis
  • Th1
  • Th2

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'CSF-chemokines in HTLV-I-associated myelopathy: CXCL10 up-regulation and therapeutic effect of interferon-α'. Together they form a unique fingerprint.

Cite this