CSF chemokine levels in relapsing neuromyelitis optica and multiple sclerosis

Koichi Narikawa, Tatsuro Misu, Kazuo Fujihara, Ichiro Nakashima, Shigeru Sato, Yasuto Itoyama

Research output: Contribution to journalArticlepeer-review

64 Citations (Scopus)

Abstract

The pathogenesis of relapsing neuromyelitis optica (RNMO) remains unknown. We, for the first time, studied the levels of four chemokines in the cerebrospinal fluid in RNMO with ELISA and compared the data with those in multiple sclerosis (MS) and control. CXCL10/IP-10 and CCL17/TARC were significantly elevated in both RNMO and MS. Conversely, CCL2/MCP-1 was significantly lower in MS, but not in RNMO, than in control. CCL11/Eotaxin was not different between groups. None of the four chemokines studied was significantly different between RNMO and MS.

Original languageEnglish
Pages (from-to)182-186
Number of pages5
JournalJournal of Neuroimmunology
Volume149
Issue number1-2
DOIs
Publication statusPublished - 2004 Apr

Keywords

  • Chemokine
  • Multiple sclerosis
  • Relapsing neuromyelitis optica

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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