Crystallography and bonding in platinum complexes with 1-methylcytosine bridging ligand

E. Zangrando; C. Mealli; F. Pichierri; L. Randaccio

Crystallography and bonding in platinum complexes with 1-methylcytosine bridging ligand

E. Zangrando, C. Mealli, F. Pichierri, L. Randaccio

Research output: Contribution to journal › Article › peer-review

Abstract

The structural aspects of dinuclear complexes of general formula trans-[(a)₂Pt(1-MeC)₂MY](n+) (where M = Pd, Cu, Hg; a = NH₃, amine; Y = neutral or monoanionic ligand; 1-MeC- = 1-methylcitosinate anion) are discussed. In these complexes the metals are bridged by two nearly coplanar nucleobases in trans position with respect to Pt which presents a square pyramidal coordination with M at the apex. The Pt-M distances are particularly short in the Pd and Cu derivatives (about 2.5 Å), while a mean value of ca. 2.8 Å was detected in the Pt-Hg ones. The metal-metal interaction in the Pt,Pd dimers (d⁸-d⁸ systems) has been studied by extended Huckel calculations and the linkage is formally analyzed by adding one and two electrons for describing the systems with d⁸-d⁹ and d⁸-d¹⁰ electron configurations.

Original language	English
Pages (from-to)	486-489
Number of pages	4
Journal	Bollettino Chimico Farmaceutico
Volume	135
Issue number	8
Publication status	Published - 1996 Sept 1
Externally published	Yes

Keywords

EHMO calculations
cisplatin
cytosine
metal complexes
structure

ASJC Scopus subject areas

Molecular Medicine

Cite this

@article{93baab1a47b8413d83d9ebd37ab32dfc,

title = "Crystallography and bonding in platinum complexes with 1-methylcytosine bridging ligand",

abstract = "The structural aspects of dinuclear complexes of general formula trans-[(a)2Pt(1-MeC)2MY](n+) (where M = Pd, Cu, Hg; a = NH3, amine; Y = neutral or monoanionic ligand; 1-MeC- = 1-methylcitosinate anion) are discussed. In these complexes the metals are bridged by two nearly coplanar nucleobases in trans position with respect to Pt which presents a square pyramidal coordination with M at the apex. The Pt-M distances are particularly short in the Pd and Cu derivatives (about 2.5 {\AA}), while a mean value of ca. 2.8 {\AA} was detected in the Pt-Hg ones. The metal-metal interaction in the Pt,Pd dimers (d8-d8 systems) has been studied by extended Huckel calculations and the linkage is formally analyzed by adding one and two electrons for describing the systems with d8-d9 and d8-d10 electron configurations.",

keywords = "EHMO calculations, cisplatin, cytosine, metal complexes, structure",

author = "E. Zangrando and C. Mealli and F. Pichierri and L. Randaccio",

year = "1996",

month = sep,

day = "1",

language = "English",

volume = "135",

pages = "486--489",

journal = "Bollettino Chimico Farmaceutico",

issn = "0006-6648",

publisher = "Societa Editoriale Farmaceutica",

number = "8",

}

TY - JOUR

T1 - Crystallography and bonding in platinum complexes with 1-methylcytosine bridging ligand

AU - Zangrando, E.

AU - Mealli, C.

AU - Pichierri, F.

AU - Randaccio, L.

PY - 1996/9/1

Y1 - 1996/9/1

N2 - The structural aspects of dinuclear complexes of general formula trans-[(a)2Pt(1-MeC)2MY](n+) (where M = Pd, Cu, Hg; a = NH3, amine; Y = neutral or monoanionic ligand; 1-MeC- = 1-methylcitosinate anion) are discussed. In these complexes the metals are bridged by two nearly coplanar nucleobases in trans position with respect to Pt which presents a square pyramidal coordination with M at the apex. The Pt-M distances are particularly short in the Pd and Cu derivatives (about 2.5 Å), while a mean value of ca. 2.8 Å was detected in the Pt-Hg ones. The metal-metal interaction in the Pt,Pd dimers (d8-d8 systems) has been studied by extended Huckel calculations and the linkage is formally analyzed by adding one and two electrons for describing the systems with d8-d9 and d8-d10 electron configurations.

AB - The structural aspects of dinuclear complexes of general formula trans-[(a)2Pt(1-MeC)2MY](n+) (where M = Pd, Cu, Hg; a = NH3, amine; Y = neutral or monoanionic ligand; 1-MeC- = 1-methylcitosinate anion) are discussed. In these complexes the metals are bridged by two nearly coplanar nucleobases in trans position with respect to Pt which presents a square pyramidal coordination with M at the apex. The Pt-M distances are particularly short in the Pd and Cu derivatives (about 2.5 Å), while a mean value of ca. 2.8 Å was detected in the Pt-Hg ones. The metal-metal interaction in the Pt,Pd dimers (d8-d8 systems) has been studied by extended Huckel calculations and the linkage is formally analyzed by adding one and two electrons for describing the systems with d8-d9 and d8-d10 electron configurations.

KW - EHMO calculations

KW - cisplatin

KW - cytosine

KW - metal complexes

KW - structure

UR - http://www.scopus.com/inward/record.url?scp=0030467512&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030467512&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0030467512

SN - 0006-6648

VL - 135

SP - 486

EP - 489

JO - Bollettino Chimico Farmaceutico

JF - Bollettino Chimico Farmaceutico

IS - 8

ER -

Crystallography and bonding in platinum complexes with 1-methylcytosine bridging ligand

Abstract

Keywords

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this