Crystallography and bonding in platinum complexes with 1-methylcytosine bridging ligand

E. Zangrando, C. Mealli, F. Pichierri, L. Randaccio

Research output: Contribution to journalArticlepeer-review

Abstract

The structural aspects of dinuclear complexes of general formula trans-[(a)2Pt(1-MeC)2MY](n+) (where M = Pd, Cu, Hg; a = NH3, amine; Y = neutral or monoanionic ligand; 1-MeC- = 1-methylcitosinate anion) are discussed. In these complexes the metals are bridged by two nearly coplanar nucleobases in trans position with respect to Pt which presents a square pyramidal coordination with M at the apex. The Pt-M distances are particularly short in the Pd and Cu derivatives (about 2.5 Å), while a mean value of ca. 2.8 Å was detected in the Pt-Hg ones. The metal-metal interaction in the Pt,Pd dimers (d8-d8 systems) has been studied by extended Huckel calculations and the linkage is formally analyzed by adding one and two electrons for describing the systems with d8-d9 and d8-d10 electron configurations.

Original languageEnglish
Pages (from-to)486-489
Number of pages4
JournalBollettino Chimico Farmaceutico
Volume135
Issue number8
Publication statusPublished - 1996 Sep 1
Externally publishedYes

Keywords

  • EHMO calculations
  • cisplatin
  • cytosine
  • metal complexes
  • structure

ASJC Scopus subject areas

  • Molecular Medicine

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