Crucial roles fo Brn1 in distal tubule formation and function in mouse kidney

Shigeyasu Nakai, Yoshinobu Sugitani, Hiroshi Sato, Sadayoshi Ito, Yukio Miura, Masaharu Ogawa, Miyuki Nishi, Kou Ichi Jishage, Osamu Minowa, Tetsuo Noda

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96 Citations (Scopus)

Abstract

This study identifies a role for the gene for the POU transcription factor Brn1 in distal tubule formation and function in the mammalian kidney. Normal development of Henle's loop (HL), the distal convoluted tubule and the macula densa was severely retarded in Brn1-deficient mice. In particular, elongation and differentiation of the developing HL was affected. In the adult kidney, Brn1 was detected only in the thick ascending limb (TAL) of HL. In addition, the expression of a number of TAL-specific genes was reduced in the Brn1+/- kidney, including Umod, Nkcc2/Slc12a1, Bsnd, Kcnj1 and Ptger3. These results suggest that Brn1 is essential for both the development and function of the nephron in the kidney.

Original languageEnglish
Pages (from-to)4751-4759
Number of pages9
JournalDevelopment
Volume130
Issue number19
DOIs
Publication statusPublished - 2003 Oct

Keywords

  • Brn1
  • Distal tubule formation
  • Henle's loop
  • Kidney
  • POU transcription factor

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

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    Nakai, S., Sugitani, Y., Sato, H., Ito, S., Miura, Y., Ogawa, M., Nishi, M., Jishage, K. I., Minowa, O., & Noda, T. (2003). Crucial roles fo Brn1 in distal tubule formation and function in mouse kidney. Development, 130(19), 4751-4759. https://doi.org/10.1242/dev.00666