Crucial role of peroxiredoxin III in placental antioxidant defense of mice

Lianqin Li; Wataru Shoji; Hiroaki Oshima; Masuo Obinata; Manabu Fukumoto; Naoko Kanno

doi:10.1016/j.febslet.2008.05.050

Crucial role of peroxiredoxin III in placental antioxidant defense of mice

Lianqin Li, Wataru Shoji, Hiroaki Oshima, Masuo Obinata, Manabu Fukumoto, Naoko Kanno

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

We observed frequent stillbirth in peroxiredoxin III (PrxIII) knockout maternal mice. Quantitative real time PCR (qRT-PCR) and Western-blot analysis revealed increased oxidative stress in placentas that were deficient in PrxIII. We did not find significant difference between PrxIII knockout maternal mice and wild-type littermates in hematological parameters, fetal number, and embryonic development. Nevertheless, we noticed enhanced expression of PrxI in erythrocytes of pregnant knockout mice. Our results provided in vivo evidence that PrxIII played a crucial role in placental antioxidant defense. Up-regulation of PrxI might provide a compensation that protected erythrocytes against oxidative damage.

Original language	English
Pages (from-to)	2431-2434
Number of pages	4
Journal	FEBS Letters
Volume	582
Issue number	16
DOIs	https://doi.org/10.1016/j.febslet.2008.05.050
Publication status	Published - 2008 Jul 9
Externally published	Yes

Keywords

Oxidative stress
Peroxiredoxin III (PrxIII)
Placenta
Stillbirth

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/j.febslet.2008.05.050

Cite this

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title = "Crucial role of peroxiredoxin III in placental antioxidant defense of mice",

abstract = "We observed frequent stillbirth in peroxiredoxin III (PrxIII) knockout maternal mice. Quantitative real time PCR (qRT-PCR) and Western-blot analysis revealed increased oxidative stress in placentas that were deficient in PrxIII. We did not find significant difference between PrxIII knockout maternal mice and wild-type littermates in hematological parameters, fetal number, and embryonic development. Nevertheless, we noticed enhanced expression of PrxI in erythrocytes of pregnant knockout mice. Our results provided in vivo evidence that PrxIII played a crucial role in placental antioxidant defense. Up-regulation of PrxI might provide a compensation that protected erythrocytes against oxidative damage.",

keywords = "Oxidative stress, Peroxiredoxin III (PrxIII), Placenta, Stillbirth",

author = "Lianqin Li and Wataru Shoji and Hiroaki Oshima and Masuo Obinata and Manabu Fukumoto and Naoko Kanno",

year = "2008",

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doi = "10.1016/j.febslet.2008.05.050",

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pages = "2431--2434",

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T1 - Crucial role of peroxiredoxin III in placental antioxidant defense of mice

AU - Li, Lianqin

AU - Shoji, Wataru

AU - Oshima, Hiroaki

AU - Obinata, Masuo

AU - Fukumoto, Manabu

AU - Kanno, Naoko

PY - 2008/7/9

Y1 - 2008/7/9

N2 - We observed frequent stillbirth in peroxiredoxin III (PrxIII) knockout maternal mice. Quantitative real time PCR (qRT-PCR) and Western-blot analysis revealed increased oxidative stress in placentas that were deficient in PrxIII. We did not find significant difference between PrxIII knockout maternal mice and wild-type littermates in hematological parameters, fetal number, and embryonic development. Nevertheless, we noticed enhanced expression of PrxI in erythrocytes of pregnant knockout mice. Our results provided in vivo evidence that PrxIII played a crucial role in placental antioxidant defense. Up-regulation of PrxI might provide a compensation that protected erythrocytes against oxidative damage.

AB - We observed frequent stillbirth in peroxiredoxin III (PrxIII) knockout maternal mice. Quantitative real time PCR (qRT-PCR) and Western-blot analysis revealed increased oxidative stress in placentas that were deficient in PrxIII. We did not find significant difference between PrxIII knockout maternal mice and wild-type littermates in hematological parameters, fetal number, and embryonic development. Nevertheless, we noticed enhanced expression of PrxI in erythrocytes of pregnant knockout mice. Our results provided in vivo evidence that PrxIII played a crucial role in placental antioxidant defense. Up-regulation of PrxI might provide a compensation that protected erythrocytes against oxidative damage.

KW - Oxidative stress

KW - Peroxiredoxin III (PrxIII)

KW - Placenta

KW - Stillbirth

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Crucial role of peroxiredoxin III in placental antioxidant defense of mice

Abstract

Keywords

ASJC Scopus subject areas

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