Crucial role of peroxiredoxin III in placental antioxidant defense of mice

Lianqin Li, Wataru Shoji, Hiroaki Oshima, Masuo Obinata, Manabu Fukumoto, Naoko Kanno

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

We observed frequent stillbirth in peroxiredoxin III (PrxIII) knockout maternal mice. Quantitative real time PCR (qRT-PCR) and Western-blot analysis revealed increased oxidative stress in placentas that were deficient in PrxIII. We did not find significant difference between PrxIII knockout maternal mice and wild-type littermates in hematological parameters, fetal number, and embryonic development. Nevertheless, we noticed enhanced expression of PrxI in erythrocytes of pregnant knockout mice. Our results provided in vivo evidence that PrxIII played a crucial role in placental antioxidant defense. Up-regulation of PrxI might provide a compensation that protected erythrocytes against oxidative damage.

Original languageEnglish
Pages (from-to)2431-2434
Number of pages4
JournalFEBS Letters
Volume582
Issue number16
DOIs
Publication statusPublished - 2008 Jul 9

Keywords

  • Oxidative stress
  • Peroxiredoxin III (PrxIII)
  • Placenta
  • Stillbirth

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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