Crosstalk of prolyl isomerases, Pin1/Essl, and cyclophilin A

Fumihiro Fujimori, Wataru Gunji, Junko Kikuchi, Tomoko Mogi, Yoko Ohashi, Tohru Makino, Akira Oyama, Koji Okuhara, Takafumi Uchida, Yasufumi Murakami

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


Previous studies have indicated that Ess1/Pin1, a gene in the parvulin family of peptidyl-prolyl isomerases (PPIases), plays an important role in regulating the G2/M transition of the cell cycle by binding cell-cycle-regulating proteins in eukaryotic cells. Although the ess1 gene has been considered to be essential in yeast, we have isolated viable ess1 deletion mutants and demonstrated, via analysis of yeast gene expression profiles using microarray techniques, a novel regulatory role for ESS1 in the G1 phase. Although the overall expression profiles in the tested strains (C110-1, W303, S288c, and RAY-3AD) were similar, marked changes were detected for a number of genes involved in the molecular action of ESS1. Among these, the expression levels of a cyclophilin A gene, also a member of the PPIase family, increased in the ess1 null mutant derived from C110-1. Subsequent treatment with cyclosporin A significantly retarded growth, which suggests that ESS1 and cyclophilin A are functionally linked in yeast cells and play important roles at the G1 phase of the cell cycle.

Original languageEnglish
Pages (from-to)181-190
Number of pages10
JournalBiochemical and biophysical research communications
Issue number1
Publication statusPublished - 2001 Nov 23
Externally publishedYes


  • Cell cycle
  • Cyclophilin A
  • Ess1
  • Microarray
  • PPIase
  • Peptydyl-prolyl cis/trans isomerase
  • Pin1

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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