Crosstalk between regulatory T cells (Tregs) and myeloid derived suppressor cells (MDSCs) during melanoma growth

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51 Citations (Scopus)

Abstract

Myeloid derived suppressor cells (MDSCa) are a heterogeneous population of cells that promote an immunosuppressive environment in tumor-bearing hosts. Recently, B7-H1 signaling has been reported to be critical for the maintainancer of regulatory T cells (Tregs), another immunosuppressive cell population. Here, we discuss the immunosuppressive function of B7-H1 on MDSCs, and the functional crosstalk between Tregs and MDSCs.

Original languageEnglish
Pages (from-to)1433-1434
Number of pages2
JournalOncoImmunology
Volume1
Issue number8
DOIs
Publication statusPublished - 2012
Externally publishedYes

Keywords

  • B7-H1
  • IL-10
  • MDSC
  • Melanoma
  • Tregs

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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