Crosstalk between histamine and T cells in allergic diseases

Mayumi Saeki, Tomoe Nishimura, Osamu Kaminuma, Hiroshi Ohtsu, Akio Mori, Takachika Hiroi

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Histamine, a prominent mediator of the symptoms and pathogenesis of allergic diseases, is produced not only by mast cells and basophils via the classical degranulation process but also by other immune cells including T cells via a neosynthesis process. Interestingly, T cells produce and are affected by histamine. Various T cell functions are also regulated by histamine via H1, H2, and H4 receptors. We recently demonstrated that T cells induce massive allergic inflammation without assistance from the immunoglobulin E (IgE)/mast cell-dependent pathway, and histamine may be involved in the development of allergic diseases via the functional modulation of and production by T cells. Based on these reports, we propose a new role of histamine and T cells in allergic diseases that differs from the established paradigm. Aside from our recent study showing the downregulation of regulatory T (Treg) cells by histamine via H1R and H4R in a murine allergic dermatitis model, the detailed roles of histamine and T cells in histamine production, expression of histamine receptors, and histamine-mediated activity for a series of T cell subsets remain to be elucidated.

Original languageEnglish
Pages (from-to)10-13
Number of pages4
JournalCurrent Immunology Reviews
Issue number1
Publication statusPublished - 2016 Apr 1


  • Allergy
  • Histamine receptor
  • Histidine decarboxylase
  • Neosynthesized histamine
  • T cells
  • Treg

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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