Crossregulation between En-2 and Wnt-1 in chick tectal development

Sayaka Sugiyama, Jun Ichi Funahashi, Jan Kitajewski, Harukazu Nakamura

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

En-1, En-2 and Wnt-1 are proposed to be essential signals for the development of the optic tectum in chick embryos. Drosophila engrailed and wingless, homologs of En (En-1 and En-2) and Wnt-1, respectively, have been shown to crossregulate each other. In the present paper, it is reported that crossregulation between En-2 and Wnt-1 is preserved in the development of the chick optic tectum. When En-2 is overexpressed by the replication competent retroviral vector, Wnt-1 is expressed ectopically at the dorsal midline of the diencephalon. When Wnt-1 is introduced extrinsically either by ectopic transplantation of mesencephalon, or by implantation of Wnt-1 producing cells, En-2 is induced ectopically at the dorsal midline of the tel- diencephalic border. Thus, ectopic expression of En-2 and Wnt-1 leads to crossregulation of each other in the chick brain. As diencephalon transdifferentiates into the optic tectum by an appropriate signal, the crossregulation of En-2 and Wnt-1 in the diencephalon may mimic the relationship required for early development in the tectum.

Original languageEnglish
Pages (from-to)157-166
Number of pages10
JournalDevelopment Growth and Differentiation
Volume40
Issue number2
DOIs
Publication statusPublished - 1998

Keywords

  • Chick
  • Correlation
  • En
  • Tectum
  • Wnt-1

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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