Cross-species analysis reveals evolving and conserved features of the nuclear factor κb (NF-κB) proteins

Grigory Ryzhakov, Ana Teixeira, David Saliba, Katrina Blazek, Tatsushi Muta, Jiannis Ragoussis, Irina A. Udalova

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Background: NF-κB regulates transcription via binding to DNA and interactions with cofactors. Results: NF-κB binding to DNA and cytosolic IκBs is conserved, whereas binding to nuclear IκBs has evolved. Conclusion: There is distinct evolutionary pressure on two NF-κB/IκB binding interfaces. Significance: The results provide inroads into IκB-specific modulation of NF-κB activity.

Original languageEnglish
Pages (from-to)11546-11554
Number of pages9
JournalJournal of Biological Chemistry
Volume288
Issue number16
DOIs
Publication statusPublished - 2013 Apr 19

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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