Cross-sensitivity of X-ray-hypersensitive cells derived from LEC strain rats to DNA-damaging agents

Toyo Okui, Daiji Endoh, Soichiro Arai, Emiko Isogai, Masanobu Hayashi

    Research output: Contribution to journalArticlepeer-review

    13 Citations (Scopus)

    Abstract

    The cross-sensitivity of X-ray-hypersensitive lung fibroblasts from LEC strain (LEC) rats to other DMA-damaging agents was examined. The LEC cells were 2- to 3-fold more sensitive to bieomycin (BLM) that induces DNA double-strand breaks, and to a cross- linking agent, mitomycin C, than the cells from WKAH strain (WKAH) rats, while they were slightly sensitive to alkylating agents, ethyl nitrosourea and N-methyl-N′-nitro-N-nitrosoguanidine, but not to UV-irradiation. Although no difference was observed in the initial yields of DNA double-strand breaks induced by BLM between LEC and WKAH cells, the repair process of DNA double-strand breaks was significantly slower in LEC cells than in WKAH cells.

    Original languageEnglish
    Pages (from-to)1067-1071
    Number of pages5
    JournalJournal of Veterinary Medical Science
    Volume58
    Issue number11
    DOIs
    Publication statusPublished - 1996 Nov

    Keywords

    • Alkylating agent
    • Bieomycin
    • Cross-sensitivity
    • LEC rat cell
    • Mitomycin C

    ASJC Scopus subject areas

    • veterinary(all)

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