Critical Roles of TRAF2 and TRAF5 in Tumor Necrosis Factor-induced NF-κB Activation and Protection from Cell Death

Kurisu Tada, Tatsuma Okazaki, Sachiko Sakon, Tomonari Kobarai, Kyoko Kurosawa, Shoji Yamaoka, Hiroshi Hashimoto, Tak Wah Mak, Hideo Yagita, Ko Okumura, Wen Chen Yeh, Hiroyasu Nakano

Research output: Contribution to journalArticlepeer-review

238 Citations (Scopus)

Abstract

Tumor necrosis factor (TNF) receptor-associated factors (TRAFs) were identified as signal transducers for the TNF receptor superfamily. However, the exact roles of TRAF2 and TRAF5 in TNF-induced NF-κB activation still remain controversial. To address this issue, we generated TRAF2 and TRAF5 double knockout (DKO) mice. TNF- but not interleukin-1-induced nuclear translocation of NF-κB was severely impaired in murine embryonic fibroblasts (MEFs) derived from DKO mice. Moreover, DKO MEFs were more susceptible to TNF-induced cytotoxicity than TRAF2 knockout MEFs. Collectively, these results indicate that both TRAF2 and TRAF5 are involved in TNF-induced NF-κB activation and protection from cell death.

Original languageEnglish
Pages (from-to)36530-36534
Number of pages5
JournalJournal of Biological Chemistry
Volume276
Issue number39
DOIs
Publication statusPublished - 2001 Sep 28
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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