Critical role of cortactin in actin ring formation and osteoclastic bone resorption

Takuma Matsubara, Akira Myoui, Fumiyo Ikeda, Kenji Hata, Hideki Yoshikawa, Riko Nishimura, Toshiyuki Yoneda

    Research output: Contribution to journalArticlepeer-review

    19 Citations (Scopus)


    Tyrosine kinase c-Src plays an essential role in ruffled border formation and bone resorption in osteoclasts; however, it is unclear how c-Src controls ruffled border formation during bone resorption. To address this question, we investigated the role of cortactin, a c-Src substrate, in osteoclasts. We found that cortactin showed colocalization with c-Src and actin rings in osteoclasts. Overexpression of cortactin stimulated actin ring formation in RAW 264.7 cells. In contrast, overexpression of Csk inhibited tyrosine phosphorylation of cortactin and binding of cortactin to c-Src. More importantly, overexertion of a mutant cortactin strongly suppressed actin ring formation and bone resorbing activity in osteoclasts. Collectively, our data indicate that cortactin controls osteoclastic bone resorption by regulating actin organization.

    Original languageEnglish
    Pages (from-to)368-372
    Number of pages5
    JournalJournal of Bone and Mineral Metabolism
    Issue number5
    Publication statusPublished - 2006 Sep


    • Cortactin
    • Osteoclast
    • c-Src

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Orthopedics and Sports Medicine
    • Endocrinology


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