Creutzfeldt-Jakob disease with florid plaques after cadaveric dura mater graft

Yoko Mochizuki; Tomohiko Mizutani; Nobuo Tajiri; Toshinori Oinuma; Norimichi Nemoto; Shigeo Kakimi; Tetsuyuki Kitamoto

doi:10.1046/j.1440-1789.2003.00489.x

Creutzfeldt-Jakob disease with florid plaques after cadaveric dura mater graft

Yoko Mochizuki, Tomohiko Mizutani, Nobuo Tajiri, Toshinori Oinuma, Norimichi Nemoto, Shigeo Kakimi, Tetsuyuki Kitamoto

MED - United Centers for Advanced Research and Translational Medicine (ART)

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

A patient with dura-associated Creutzfeldt-Jakob disease (D-CJD) which occurred about 15 years after a dura mater graft is reported in the present study. The prion protein gene analysis disclosed no mutation. The D-CJD was atypical in: (i), the long interval between the onset of ataxia and the occurrence of dementia; (ii), the presence of transient myoclonus; and (iii), the presence of florid plaques in the brain. The electron-microscopic findings showed bundles of amyloid filaments which radiated from the center of the plaques without degenerating neurites. This case of D-CJD may belong to a new subtype of D-CJD.

Original language	English
Pages (from-to)	136-140
Number of pages	5
Journal	Neuropathology
Volume	23
Issue number	2
DOIs	https://doi.org/10.1046/j.1440-1789.2003.00489.x
Publication status	Published - 2003 Jun 1

Keywords

Cadaveric dura mater graft
Creutzfeldt-Jakob disease
Florid plaque
Prion protein

ASJC Scopus subject areas

Pathology and Forensic Medicine
Neuroscience(all)

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10.1046/j.1440-1789.2003.00489.x

Cite this

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title = "Creutzfeldt-Jakob disease with florid plaques after cadaveric dura mater graft",

abstract = "A patient with dura-associated Creutzfeldt-Jakob disease (D-CJD) which occurred about 15 years after a dura mater graft is reported in the present study. The prion protein gene analysis disclosed no mutation. The D-CJD was atypical in: (i), the long interval between the onset of ataxia and the occurrence of dementia; (ii), the presence of transient myoclonus; and (iii), the presence of florid plaques in the brain. The electron-microscopic findings showed bundles of amyloid filaments which radiated from the center of the plaques without degenerating neurites. This case of D-CJD may belong to a new subtype of D-CJD.",

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AU - Mochizuki, Yoko

AU - Mizutani, Tomohiko

AU - Tajiri, Nobuo

AU - Oinuma, Toshinori

AU - Nemoto, Norimichi

AU - Kakimi, Shigeo

AU - Kitamoto, Tetsuyuki

PY - 2003/6/1

Y1 - 2003/6/1

N2 - A patient with dura-associated Creutzfeldt-Jakob disease (D-CJD) which occurred about 15 years after a dura mater graft is reported in the present study. The prion protein gene analysis disclosed no mutation. The D-CJD was atypical in: (i), the long interval between the onset of ataxia and the occurrence of dementia; (ii), the presence of transient myoclonus; and (iii), the presence of florid plaques in the brain. The electron-microscopic findings showed bundles of amyloid filaments which radiated from the center of the plaques without degenerating neurites. This case of D-CJD may belong to a new subtype of D-CJD.

AB - A patient with dura-associated Creutzfeldt-Jakob disease (D-CJD) which occurred about 15 years after a dura mater graft is reported in the present study. The prion protein gene analysis disclosed no mutation. The D-CJD was atypical in: (i), the long interval between the onset of ataxia and the occurrence of dementia; (ii), the presence of transient myoclonus; and (iii), the presence of florid plaques in the brain. The electron-microscopic findings showed bundles of amyloid filaments which radiated from the center of the plaques without degenerating neurites. This case of D-CJD may belong to a new subtype of D-CJD.

KW - Cadaveric dura mater graft

KW - Creutzfeldt-Jakob disease

KW - Florid plaque

KW - Prion protein

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Creutzfeldt-Jakob disease with florid plaques after cadaveric dura mater graft

Abstract

Keywords

ASJC Scopus subject areas

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