Creutzfeldt-Jakob disease with florid plaques after cadaveric dura mater graft

Yoko Mochizuki, Tomohiko Mizutani, Nobuo Tajiri, Toshinori Oinuma, Norimichi Nemoto, Shigeo Kakimi, Tetsuyuki Kitamoto

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


A patient with dura-associated Creutzfeldt-Jakob disease (D-CJD) which occurred about 15 years after a dura mater graft is reported in the present study. The prion protein gene analysis disclosed no mutation. The D-CJD was atypical in: (i), the long interval between the onset of ataxia and the occurrence of dementia; (ii), the presence of transient myoclonus; and (iii), the presence of florid plaques in the brain. The electron-microscopic findings showed bundles of amyloid filaments which radiated from the center of the plaques without degenerating neurites. This case of D-CJD may belong to a new subtype of D-CJD.

Original languageEnglish
Pages (from-to)136-140
Number of pages5
Issue number2
Publication statusPublished - 2003 Jun 1


  • Cadaveric dura mater graft
  • Creutzfeldt-Jakob disease
  • Florid plaque
  • Prion protein

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)


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