Abstract
A patient with dura-associated Creutzfeldt-Jakob disease (D-CJD) which occurred about 15 years after a dura mater graft is reported in the present study. The prion protein gene analysis disclosed no mutation. The D-CJD was atypical in: (i), the long interval between the onset of ataxia and the occurrence of dementia; (ii), the presence of transient myoclonus; and (iii), the presence of florid plaques in the brain. The electron-microscopic findings showed bundles of amyloid filaments which radiated from the center of the plaques without degenerating neurites. This case of D-CJD may belong to a new subtype of D-CJD.
| Original language | English |
|---|---|
| Pages (from-to) | 136-140 |
| Number of pages | 5 |
| Journal | Neuropathology |
| Volume | 23 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2003 Jun 1 |
Keywords
- Cadaveric dura mater graft
- Creutzfeldt-Jakob disease
- Florid plaque
- Prion protein
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Neuroscience(all)
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Cite this
Mochizuki, Y., Mizutani, T., Tajiri, N., Oinuma, T., Nemoto, N., Kakimi, S., & Kitamoto, T. (2003). Creutzfeldt-Jakob disease with florid plaques after cadaveric dura mater graft. Neuropathology, 23(2), 136-140. https://doi.org/10.1046/j.1440-1789.2003.00489.x