Creutzfeldt-Jakob disease with amyloid angiopathy: diagnosis by immunological analyses and transmission experiments

J. Tateishi, T. Kitamoto, K. Doh-ura, J. W. Boellaard, J. Peiffer

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

It was difficult to make a definite pathological diagnosis in a 73-year-old man with Creutzfeldt-Jakob disease (CJD) due to extensive amyloid angiopathy which lacked any severe spongiform changes. Immunostaining using anti-prion protein (PrP) antibody revealed fine granular deposits in the gray matter, after hydrolytic autoclaving pretreatment on tissue sections. Western blotting also revealed an abnormal isoform of PrP, but PrP gene analysis did not show any abnormalities. The primary transmission experiments were repeated three times and induced spongiform encephalopathy in a few mice after a long incubation period.

Original languageEnglish
Pages (from-to)559-563
Number of pages5
JournalActa neuropathologica
Volume83
Issue number5
DOIs
Publication statusPublished - 1992 Apr 1
Externally publishedYes

Keywords

  • Amyloid angiopathy
  • Creutzfeldt-Jakob disease
  • Experimental transmission
  • Immunohistochemistry
  • Prion protein

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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