Creutzfeldt-Jakob disease with amyloid angiopathy: diagnosis by immunological analyses and transmission experiments

J. Tateishi; T. Kitamoto; K. Doh-ura; J. W. Boellaard; J. Peiffer

doi:10.1007/BF00310037

Creutzfeldt-Jakob disease with amyloid angiopathy: diagnosis by immunological analyses and transmission experiments

J. Tateishi, T. Kitamoto, K. Doh-ura, J. W. Boellaard, J. Peiffer

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

It was difficult to make a definite pathological diagnosis in a 73-year-old man with Creutzfeldt-Jakob disease (CJD) due to extensive amyloid angiopathy which lacked any severe spongiform changes. Immunostaining using anti-prion protein (PrP) antibody revealed fine granular deposits in the gray matter, after hydrolytic autoclaving pretreatment on tissue sections. Western blotting also revealed an abnormal isoform of PrP, but PrP gene analysis did not show any abnormalities. The primary transmission experiments were repeated three times and induced spongiform encephalopathy in a few mice after a long incubation period.

Original language	English
Pages (from-to)	559-563
Number of pages	5
Journal	Acta neuropathologica
Volume	83
Issue number	5
DOIs	https://doi.org/10.1007/BF00310037
Publication status	Published - 1992 Apr 1
Externally published	Yes

Keywords

Amyloid angiopathy
Creutzfeldt-Jakob disease
Experimental transmission
Immunohistochemistry
Prion protein

ASJC Scopus subject areas

Pathology and Forensic Medicine
Clinical Neurology
Cellular and Molecular Neuroscience

Access to Document

10.1007/BF00310037

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title = "Creutzfeldt-Jakob disease with amyloid angiopathy: diagnosis by immunological analyses and transmission experiments",

abstract = "It was difficult to make a definite pathological diagnosis in a 73-year-old man with Creutzfeldt-Jakob disease (CJD) due to extensive amyloid angiopathy which lacked any severe spongiform changes. Immunostaining using anti-prion protein (PrP) antibody revealed fine granular deposits in the gray matter, after hydrolytic autoclaving pretreatment on tissue sections. Western blotting also revealed an abnormal isoform of PrP, but PrP gene analysis did not show any abnormalities. The primary transmission experiments were repeated three times and induced spongiform encephalopathy in a few mice after a long incubation period.",

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AU - Tateishi, J.

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AU - Doh-ura, K.

AU - Boellaard, J. W.

AU - Peiffer, J.

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KW - Experimental transmission

KW - Immunohistochemistry

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