Creutzfeldt-jakob disease transmitted by a cadaveric dura mater graft

Shozo Yamada; Tadashi Aiba; Yuzo Endo; Mitsuru Hara; Tetsuyuki Kitamoto; Jun Tateishi

doi:10.1227/00006123-199404000-00027

Creutzfeldt-jakob disease transmitted by a cadaveric dura mater graft

Shozo Yamada, Tadashi Aiba, Yuzo Endo, Mitsuru Hara, Tetsuyuki Kitamoto, Jun Tateishi

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Abstract

WE REPORT A case of Creutzfeldt-Jakob disease developing in a 31-year-old woman 56 months after she received a cadaveric dura mater graft after the removal of a giant pituitary adenoma. Creutzfeldt-Jakob disease was confirmed by a brain autopsy and the existence of an abnormal isoform of prion protein, verified by both immunohistochemical and Western blot analysis. Moreover, prion protein gene analysis was shown in this case to possess a wild-type genotype. The characteristics of Creutzfeldt-Jakob disease after a cadaveric dura mater graft are reviewed and discussed.

Original language	English
Pages (from-to)	740-744
Number of pages	5
Journal	Neurosurgery
Volume	34
Issue number	4
DOIs	https://doi.org/10.1227/00006123-199404000-00027
Publication status	Published - 1994 Apr
Externally published	Yes

Keywords

Cadaveric dura
Creutzfeldt-jakob disease
Gene analysis
Immunohistochemistry
Prion protein
Western blot analysis

ASJC Scopus subject areas

Surgery
Clinical Neurology

Access to Document

10.1227/00006123-199404000-00027

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title = "Creutzfeldt-jakob disease transmitted by a cadaveric dura mater graft",

abstract = "WE REPORT A case of Creutzfeldt-Jakob disease developing in a 31-year-old woman 56 months after she received a cadaveric dura mater graft after the removal of a giant pituitary adenoma. Creutzfeldt-Jakob disease was confirmed by a brain autopsy and the existence of an abnormal isoform of prion protein, verified by both immunohistochemical and Western blot analysis. Moreover, prion protein gene analysis was shown in this case to possess a wild-type genotype. The characteristics of Creutzfeldt-Jakob disease after a cadaveric dura mater graft are reviewed and discussed.",

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AU - Yamada, Shozo

AU - Aiba, Tadashi

AU - Endo, Yuzo

AU - Hara, Mitsuru

AU - Kitamoto, Tetsuyuki

AU - Tateishi, Jun

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N2 - WE REPORT A case of Creutzfeldt-Jakob disease developing in a 31-year-old woman 56 months after she received a cadaveric dura mater graft after the removal of a giant pituitary adenoma. Creutzfeldt-Jakob disease was confirmed by a brain autopsy and the existence of an abnormal isoform of prion protein, verified by both immunohistochemical and Western blot analysis. Moreover, prion protein gene analysis was shown in this case to possess a wild-type genotype. The characteristics of Creutzfeldt-Jakob disease after a cadaveric dura mater graft are reviewed and discussed.

AB - WE REPORT A case of Creutzfeldt-Jakob disease developing in a 31-year-old woman 56 months after she received a cadaveric dura mater graft after the removal of a giant pituitary adenoma. Creutzfeldt-Jakob disease was confirmed by a brain autopsy and the existence of an abnormal isoform of prion protein, verified by both immunohistochemical and Western blot analysis. Moreover, prion protein gene analysis was shown in this case to possess a wild-type genotype. The characteristics of Creutzfeldt-Jakob disease after a cadaveric dura mater graft are reviewed and discussed.

KW - Cadaveric dura

KW - Creutzfeldt-jakob disease

KW - Gene analysis

KW - Immunohistochemistry

KW - Prion protein

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