Abstract
WE REPORT A case of Creutzfeldt-Jakob disease developing in a 31-year-old woman 56 months after she received a cadaveric dura mater graft after the removal of a giant pituitary adenoma. Creutzfeldt-Jakob disease was confirmed by a brain autopsy and the existence of an abnormal isoform of prion protein, verified by both immunohistochemical and Western blot analysis. Moreover, prion protein gene analysis was shown in this case to possess a wild-type genotype. The characteristics of Creutzfeldt-Jakob disease after a cadaveric dura mater graft are reviewed and discussed.
Original language | English |
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Pages (from-to) | 740-744 |
Number of pages | 5 |
Journal | Neurosurgery |
Volume | 34 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1994 Apr |
Externally published | Yes |
Keywords
- Cadaveric dura
- Creutzfeldt-jakob disease
- Gene analysis
- Immunohistochemistry
- Prion protein
- Western blot analysis
ASJC Scopus subject areas
- Surgery
- Clinical Neurology