Creutzfeldt-jakob disease transmitted by a cadaveric dura mater graft

Shozo Yamada, Tadashi Aiba, Yuzo Endo, Mitsuru Hara, Tetsuyuki Kitamoto, Jun Tateishi

Research output: Contribution to journalArticlepeer-review

64 Citations (Scopus)

Abstract

WE REPORT A case of Creutzfeldt-Jakob disease developing in a 31-year-old woman 56 months after she received a cadaveric dura mater graft after the removal of a giant pituitary adenoma. Creutzfeldt-Jakob disease was confirmed by a brain autopsy and the existence of an abnormal isoform of prion protein, verified by both immunohistochemical and Western blot analysis. Moreover, prion protein gene analysis was shown in this case to possess a wild-type genotype. The characteristics of Creutzfeldt-Jakob disease after a cadaveric dura mater graft are reviewed and discussed.

Original languageEnglish
Pages (from-to)740-744
Number of pages5
JournalNeurosurgery
Volume34
Issue number4
DOIs
Publication statusPublished - 1994 Apr
Externally publishedYes

Keywords

  • Cadaveric dura
  • Creutzfeldt-jakob disease
  • Gene analysis
  • Immunohistochemistry
  • Prion protein
  • Western blot analysis

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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