CREB required for the stability of new and reactivated fear memories

Satoshi Kida, Sheena A. Josselyn, Sandra Penña De Ortiz, Jeffrey H. Kogan, Itzamarie Chevere, Shoichi Masushige, Alcino J. Silva

Research output: Contribution to journalArticlepeer-review

501 Citations (Scopus)

Abstract

The cAMP-responsive element binding protein (CREB) family of transcription factors is thought to be critical in memory formation. To define the role of CREB in distinct memory processes, we derived transgenic mice with an inducible and reversible CREB repressor by fusing CREBS133A to a tamoxifen (TAM)-dependent mutant of an estrogen receptor ligand-binding domain (LBD). We found that CREB is crucial for the consolidation of long-term conditioned fear memories, but not for encoding, storage or retrieval of these memories. Our studies also showed that CREB is required for the stability of reactivated or retrieved conditioned fear memories. Although the transcriptional processes necessary for the stability of initial and reactivated memories differ, CREB is required for both. The findings presented here delineate the memory processes that require CREB and demonstrate the power of LBD-inducible transgenic systems in the study of complex cognitive processes.

Original languageEnglish
Pages (from-to)348-355
Number of pages8
JournalNature Neuroscience
Volume5
Issue number4
DOIs
Publication statusPublished - 2002

ASJC Scopus subject areas

  • Neuroscience(all)

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