COVID-19 infection and nanomedicine applications for development of vaccines and therapeutics: An overview and future perspectives based on polymersomes

Mohammad A.I. Al-Hatamleh, Ma'mon M. Hatmal, Walhan Alshaer, Engku Nur Syafirah E.A. Rahman, Manali Haniti Mohd-Zahid, Dina M. Alhaj-Qasem, Chan Yean Yean, Iskandar Z. Alias, Juhana Jaafar, Khalid Ferji, Jean Luc Six, Vuk Uskoković, Hiroshi Yabu, Rohimah Mohamud

Research output: Contribution to journalArticlepeer-review

Abstract

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which emerged in December 2019 and caused the coronavirus disease 2019 (COVID-19) pandemic, took the world by surprise with an unprecedented public health emergency. Since this pandemic began, extraordinary efforts have been made by scientists to understand the pathogenesis of COVID-19, and to fight the infection by providing various preventive, diagnostic and treatment opportunities based on either novel hypotheses or past experiences. Despite all the achievements, COVID-19 continues to be an accelerating health threat with no specifically approved vaccine or therapy. This review highlights the recent advances in COVID-19 infection, with a particular emphasis on nanomedicine applications that can help in the development of effective vaccines or therapeutics against COVID-19. A novel future perspective has been proposed in this review based on utilizing polymersome nano-objects for effectively suppressing the cytokine storm, which may reduce the severity of COVID-19 infection.

Original languageEnglish
Article number173930
JournalEuropean Journal of Pharmacology
Volume896
DOIs
Publication statusPublished - 2021 Apr 5

Keywords

  • 2019-nCoV
  • Coronavirus
  • Cytokine storm
  • Nanomedicine
  • SARS-CoV-2

ASJC Scopus subject areas

  • Pharmacology

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