Covalent protein labeling with a lanthanide complex and its application to photoluminescence lifetime-based multicolor bioimaging

Shin Mizukami, Taku Yamamoto, Akimasa Yoshimura, Shuji Watanabe, Kazuya Kikuchi

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)

Abstract

Better late â∥ï Lanthanide-based time-resolved luminescence imaging of proteins is a promising technology. A novel luminescent lanthanide probe (see picture, TPA-Eu) for mutant β-lactamase-based protein labeling system (BL-tag) is used to selectively image cell-surface proteins (POIs) in the presence of autofluorescent background signals, thus enabling imaging with serum.

Original languageEnglish
Pages (from-to)8750-8752
Number of pages3
JournalAngewandte Chemie - International Edition
Volume50
Issue number37
DOIs
Publication statusPublished - 2011 Sep 5
Externally publishedYes

Keywords

  • imaging agents
  • labeling probes
  • proteins
  • time-resolved luminescence

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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