Coupling effects of thiol and urea-type groups for promotion of oxidative protein folding

Shunsuke Okada; Motonori Matsusaki; Kenta Arai; Yuji Hidaka; Kenji Inaba; Masaki Okumura; Takahiro Muraoka

doi:10.1039/c8cc08657e

Coupling effects of thiol and urea-type groups for promotion of oxidative protein folding

Shunsuke Okada, Motonori Matsusaki, Kenta Arai, Yuji Hidaka, Kenji Inaba, Masaki Okumura, Takahiro Muraoka

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Coupling of thiol and urea-type-NHC(═X)NH₂ (X = O or NH) groups is effective in promoting oxidative protein folding. In particular, a thiol compound coupled with a guanidyl (X = NH) group significantly accelerates the rates of folding processes and enhances the yields of native proteins.

Original language	English
Pages (from-to)	759-762
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	6
DOIs	https://doi.org/10.1039/c8cc08657e
Publication status	Published - 2019

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "Coupling of thiol and urea-type-NHC(═X)NH2 (X = O or NH) groups is effective in promoting oxidative protein folding. In particular, a thiol compound coupled with a guanidyl (X = NH) group significantly accelerates the rates of folding processes and enhances the yields of native proteins.",

author = "Shunsuke Okada and Motonori Matsusaki and Kenta Arai and Yuji Hidaka and Kenji Inaba and Masaki Okumura and Takahiro Muraoka",

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AU - Inaba, Kenji

AU - Okumura, Masaki

AU - Muraoka, Takahiro

PY - 2019

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