Cortical laminar necrosis and central pontine myelinolysis in a patient with Sheehan syndrome and severe hyponatremia

Masaru Shoji, Tokihisa Kimura, Kozo Ota, Masahiro Ohta, Kazutoshi Sato, Tadasu Yamamoto, Takeharu Funyu, Takefumi Mori, Maki Tateyama, Keishi Abe

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Hypoxic encephalopathy and osmotic demyelination are independent clinical entities. We describe a rare case with these two complications as demonstrated by magnetic resonance imaging (MRI). A 58-year-old woman had adrenal crises twice a decade due to Sheehan syndrome. At the second crisis, hyponatremia was remarkable with consciousness disturbance which was rapidly corrected by intraveneous administration of glucocorticoid and hypertonic saline. The maneuver improved consciousness disturbance, but resulted in hypokalemic ventricular fibrillation with circulatory failure. After the normalization of the circulation, however, her consciousness level deteriorated again. Repeated brain MRI revealed acute and chronic phases of cortical laminar necrosis and central pontine myelinolysis.

Original languageEnglish
Pages (from-to)427-431
Number of pages5
JournalInternal Medicine
Volume35
Issue number5
DOIs
Publication statusPublished - 1996 May

Keywords

  • Adrenal crisis
  • Anoxic encephalopathy
  • Empty sella
  • Magnetic resonance imaging
  • Panhypopituitarism

ASJC Scopus subject areas

  • Internal Medicine

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