Corrosion of metallic biomaterials in cell culture environments

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24 Citations (Scopus)


The need for reliability and functionality in metallic biomaterials is increasing. On the other hand, evaluation of corrosion behavior and other surface properties is currently carried out in simple physiological solutions formulated without examining the influence of characteristic factors in vivo, especially in the presence of cells. The resulting problem is that the corrosion behavior obtained in these simple solutions does not always correlate with that observed in vivo. Electrochemical measurements of metallic biomaterials in a cell culture environment using fibroblasts revealed that the presence of fibroblasts retards the diffusion of ions and molecules near the cells on the surface of materials. The diffusion retardation leads to the decrease of cathodic reaction of dissolved oxygen on several metallic biomaterials. Further, it sometimes leads to a decrease in the protectiveness of the passive films of metallic biomaterials like 316L steel having a rather lower corrosion resistance than Ti. This is because the accumulation of dissolved metal ions can cause medium acidification. These results show that the presence of cells is not a negligible corrosion factor. Therefore, to accurately evaluate and to encourage the improvement of surface properties, the (surface) interaction between metallic biomaterials and the tissue to which the material will attach, should be elucidated. Understanding the characteristic corrosion factors in each part of the body is necessary to develop a simple but sufficient environment for the evaluation of various surface properties. Electrochemical measurements in a cell culture environment are useful for such an elucidation.

Original languageEnglish
Pages (from-to)41-44
Number of pages4
JournalElectrochemical Society Interface
Issue number2
Publication statusPublished - 2008 Jun
Externally publishedYes

ASJC Scopus subject areas

  • Electrochemistry


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