TY - JOUR
T1 - Correspondence of cue activity to reward activity in the macaque orbitofrontal cortex
AU - Hosokawa, Takayuki
AU - Kato, Keichiro
AU - Inoue, Masato
AU - Mikami, Akichika
PY - 2005/12/9
Y1 - 2005/12/9
N2 - It has been reported that neurons in the orbitofrontal cortex (OFC) respond to emotionally significant events such as reward-predicting cues and/or the reward itself. The responses to reward-predicting cues are considered to carry the information of the predicted reward. However, few studies have focused on the relationship of the neuronal activity during a cue period with that during a reward period. We can infer that the cue responses of OFC neurons are correlated to the reward responses if they carry the information of the predicted reward. In this study, we focused on neurons that showed responses during both the cue and reward periods, and compared the response characteristics between these periods. We found 94 of 369 OFC neurons showed significant responses during both the cue and reward periods, and 43 of which preserved their selectivity between these periods. Furthermore, population analysis showed that stronger cue responses corresponded to stronger reward responses, and stronger reward responses corresponded to stronger cue responses. These results suggest that individual neurons in the OFC associate visual information with reward information, and contribute to the prediction of future rewards by forming reward representations.
AB - It has been reported that neurons in the orbitofrontal cortex (OFC) respond to emotionally significant events such as reward-predicting cues and/or the reward itself. The responses to reward-predicting cues are considered to carry the information of the predicted reward. However, few studies have focused on the relationship of the neuronal activity during a cue period with that during a reward period. We can infer that the cue responses of OFC neurons are correlated to the reward responses if they carry the information of the predicted reward. In this study, we focused on neurons that showed responses during both the cue and reward periods, and compared the response characteristics between these periods. We found 94 of 369 OFC neurons showed significant responses during both the cue and reward periods, and 43 of which preserved their selectivity between these periods. Furthermore, population analysis showed that stronger cue responses corresponded to stronger reward responses, and stronger reward responses corresponded to stronger cue responses. These results suggest that individual neurons in the OFC associate visual information with reward information, and contribute to the prediction of future rewards by forming reward representations.
KW - Monkey
KW - Prediction
KW - Reward representation
KW - The orbitofrontal cortex
KW - Visual information
UR - http://www.scopus.com/inward/record.url?scp=24644456108&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=24644456108&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2005.07.055
DO - 10.1016/j.neulet.2005.07.055
M3 - Article
C2 - 16118036
AN - SCOPUS:24644456108
VL - 389
SP - 146
EP - 151
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 3
ER -