Correlations between extent of X-ray infiltration and levels of serum C-reactive protein in adult non-severe community-acquired pneumonia

Maki Tamayose; Jiro Fujita; Gretchen Parrott; Kazuya Miyagi; Tatsuji Maeshiro; Tetsuo Hirata; Futoshi Higa; Masao Tateyama; Akira Watanabe; Nobuki Aoki; Yoshihito Niki; Jun ichi Kadota; Katsunori Yanagihara; Mitsuo Kaku; Seiji Hori; Shigeru Kohno

doi:10.1016/j.jiac.2015.02.009

Correlations between extent of X-ray infiltration and levels of serum C-reactive protein in adult non-severe community-acquired pneumonia

Maki Tamayose, Jiro Fujita, Gretchen Parrott, Kazuya Miyagi, Tatsuji Maeshiro, Tetsuo Hirata, Futoshi Higa, Masao Tateyama, Akira Watanabe, Nobuki Aoki, Yoshihito Niki, Jun ichi Kadota, Katsunori Yanagihara, Mitsuo Kaku, Seiji Hori, Shigeru Kohno

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Pneumonia cases can vary in both severity and chest X-ray findings. Elevated C-reactive protein (CRP) levels may be an indicator of disease severity. We retrospectively evaluated factors correlated with the extent of chest X-ray infiltration both in community-acquired pneumonia (CAP) and a subgroup of cases with pneumococcal pneumonia. In a clinical study that evaluated the efficacy of sitafloxacin, 137 patients with CAP had been previously enrolled. In our study, 75 patients with pneumococcal pneumonia were identified among these 137 CAP patients. The extent of chest X-ray infiltration was scored and correlations with age, sex, body temperature, white blood cell (WBC) count, and CRP levels were analyzed using multivariate analysis with logistic regression. Significant correlations were observed between the extent of chest X-ray infiltration and CRP levels in both CAP and pneumococcal pneumonia. Our data indicates that CRP is a valuable and informative resource that could reflect the severity of pneumonia in cases of both CAP and pneumococcal pneumonia.

Original language	English
Pages (from-to)	456-463
Number of pages	8
Journal	Journal of Infection and Chemotherapy
Volume	21
Issue number	6
DOIs	https://doi.org/10.1016/j.jiac.2015.02.009
Publication status	Published - 2015 Jun 1

Keywords

C-reactive protein
Chest X-ray infiltration
Community-acquired pneumonia
Streptococcus pneumoniae

ASJC Scopus subject areas

Microbiology (medical)
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jiac.2015.02.009

Cite this

Tamayose, M., Fujita, J., Parrott, G., Miyagi, K., Maeshiro, T., Hirata, T., Higa, F., Tateyama, M., Watanabe, A., Aoki, N., Niki, Y., Kadota, J. I., Yanagihara, K., Kaku, M., Hori, S., & Kohno, S. (2015). Correlations between extent of X-ray infiltration and levels of serum C-reactive protein in adult non-severe community-acquired pneumonia. Journal of Infection and Chemotherapy, 21(6), 456-463. https://doi.org/10.1016/j.jiac.2015.02.009

Tamayose, M, Fujita, J, Parrott, G, Miyagi, K, Maeshiro, T, Hirata, T, Higa, F, Tateyama, M, Watanabe, A, Aoki, N, Niki, Y, Kadota, JI, Yanagihara, K, Kaku, M, Hori, S & Kohno, S 2015, 'Correlations between extent of X-ray infiltration and levels of serum C-reactive protein in adult non-severe community-acquired pneumonia', Journal of Infection and Chemotherapy, vol. 21, no. 6, pp. 456-463. https://doi.org/10.1016/j.jiac.2015.02.009

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abstract = "Pneumonia cases can vary in both severity and chest X-ray findings. Elevated C-reactive protein (CRP) levels may be an indicator of disease severity. We retrospectively evaluated factors correlated with the extent of chest X-ray infiltration both in community-acquired pneumonia (CAP) and a subgroup of cases with pneumococcal pneumonia. In a clinical study that evaluated the efficacy of sitafloxacin, 137 patients with CAP had been previously enrolled. In our study, 75 patients with pneumococcal pneumonia were identified among these 137 CAP patients. The extent of chest X-ray infiltration was scored and correlations with age, sex, body temperature, white blood cell (WBC) count, and CRP levels were analyzed using multivariate analysis with logistic regression. Significant correlations were observed between the extent of chest X-ray infiltration and CRP levels in both CAP and pneumococcal pneumonia. Our data indicates that CRP is a valuable and informative resource that could reflect the severity of pneumonia in cases of both CAP and pneumococcal pneumonia.",

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AU - Tamayose, Maki

AU - Fujita, Jiro

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AU - Miyagi, Kazuya

AU - Maeshiro, Tatsuji

AU - Hirata, Tetsuo

AU - Higa, Futoshi

AU - Tateyama, Masao

AU - Watanabe, Akira

AU - Aoki, Nobuki

AU - Niki, Yoshihito

AU - Kadota, Jun ichi

AU - Yanagihara, Katsunori

AU - Kaku, Mitsuo

AU - Hori, Seiji

AU - Kohno, Shigeru

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N2 - Pneumonia cases can vary in both severity and chest X-ray findings. Elevated C-reactive protein (CRP) levels may be an indicator of disease severity. We retrospectively evaluated factors correlated with the extent of chest X-ray infiltration both in community-acquired pneumonia (CAP) and a subgroup of cases with pneumococcal pneumonia. In a clinical study that evaluated the efficacy of sitafloxacin, 137 patients with CAP had been previously enrolled. In our study, 75 patients with pneumococcal pneumonia were identified among these 137 CAP patients. The extent of chest X-ray infiltration was scored and correlations with age, sex, body temperature, white blood cell (WBC) count, and CRP levels were analyzed using multivariate analysis with logistic regression. Significant correlations were observed between the extent of chest X-ray infiltration and CRP levels in both CAP and pneumococcal pneumonia. Our data indicates that CRP is a valuable and informative resource that could reflect the severity of pneumonia in cases of both CAP and pneumococcal pneumonia.

AB - Pneumonia cases can vary in both severity and chest X-ray findings. Elevated C-reactive protein (CRP) levels may be an indicator of disease severity. We retrospectively evaluated factors correlated with the extent of chest X-ray infiltration both in community-acquired pneumonia (CAP) and a subgroup of cases with pneumococcal pneumonia. In a clinical study that evaluated the efficacy of sitafloxacin, 137 patients with CAP had been previously enrolled. In our study, 75 patients with pneumococcal pneumonia were identified among these 137 CAP patients. The extent of chest X-ray infiltration was scored and correlations with age, sex, body temperature, white blood cell (WBC) count, and CRP levels were analyzed using multivariate analysis with logistic regression. Significant correlations were observed between the extent of chest X-ray infiltration and CRP levels in both CAP and pneumococcal pneumonia. Our data indicates that CRP is a valuable and informative resource that could reflect the severity of pneumonia in cases of both CAP and pneumococcal pneumonia.

KW - C-reactive protein

KW - Chest X-ray infiltration

KW - Community-acquired pneumonia

KW - Streptococcus pneumoniae

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Correlations between extent of X-ray infiltration and levels of serum C-reactive protein in adult non-severe community-acquired pneumonia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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