Correlation of World Health Organization 2010 Classification for Gastroenteropancreatic Neuroendocrine Neoplasms with the Prognosis of Ovarian Neuroendocrine Neoplasms: Kansai Clinical Oncology Group-Protocol Review Committee/Intergroup Study

Kentaro Kai, Kaei Nasu, Haruto Nishida, Tsutomu Daa, Ayumi Shikama, Takaya Shiozaki, Masamitsu Kurakazu, Mitsutake Yano, Yuko Imamura, Hideki Tokunaga, Kazuto Tasaki, Yasushi Iida, Yuki Yamada, Hiroyuki Morisawa, Satoshi Nakagawa, Etsuko Fujimoto, Tomohiko Tsuruta, Harunobu Matsumoto, Atsushi Arakawa, Michiko NonakaHirokuni Takano, Takashi Ushiwaka, Taisuke Mori, Kimihiko Ito, Takashi Motohashi, Norihiro Teramoto, Takashi Yamada

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Background: In 2014, the World Health Organization (WHO) released a classification system introducing neuroendocrine neoplasms (NENs) of the female reproductive tract, excluding the ovaries. This study aimed to evaluate whether retrospective adaption of the gastroenteropancreatic (GEP)-NEN classification is feasible for ovarian NENs (O-NENs) and correlates with prognosis. Methods: Sixty-eight patients diagnosed with carcinoid, small cell carcinoma (pulmonary type), paraganglioma, non-small/large cell neuroendocrine carcinoma (NEC), mixed NEC, or undifferentiated carcinomas at 20 institutions in Japan were included in this retrospective cross-sectional study. We identified O-NENs through central pathological review using a common slide set, followed by reclassification according to WHO 2010 guidelines for GEP-NENs. A proportional hazards model was used to assess the association of prognostic factors (age, stage, performance status, histology, and residual disease) with overall survival (OS) and progression-free survival (PFS). Results: Of the 68 enrolled patients, 48 were eligible for analysis. All carcinoids (n = 32) were reclassified as NET G1/G2, whereas 14 of 16 carcinomas were reclassified as NEC/mixed adeno-NEC (MANEC) (Fisher's exact test; p < 0.01). The OS/PFS was 49.0/42.5 months and 6.5/3.9 months for NET G1/G2 and NEC/MANEC, respectively. Histology revealed that NEC/MANEC was associated with increased risk of death (HR = 48.0; 95% CI, 3.93-586; p < 0.01) and disease progression (HR = 51.6; 95% CI, 5.54-480; p < 0.01). Conclusion: Retrospective adaption of GEP-NEN classification to O-NENs is feasible and correlates well with the prognosis of O-NENs. This classification could be introduced for ovarian tumors.

Original languageEnglish
Pages (from-to)320-329
Number of pages10
JournalNeuroendocrinology
Volume111
Issue number4
DOIs
Publication statusPublished - 2021 Mar
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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