TY - GEN
T1 - Correlation between Red Blood Cell Aggregation and Blood Glucose Level
AU - Fukase, Akiyo
AU - Nagasawa, Kanta
AU - Mori, Shohei
AU - Arakawa, Mototaka
AU - Yashiro, Satoshi
AU - Ishigaki, Yasushi
AU - Kanai, Hiroshi
N1 - Funding Information:
This work was partially supported by JSPS KAKENHI 18K04160.
PY - 2019/10
Y1 - 2019/10
N2 - High blood glucose level (BGL) is related to the high viscosity of blood. Red blood cells (RBCs) tend to gather each other in the condition of high viscosity. Backscattered echoes become high as RBCs aggregate. Therefore, the intensity of backscattered echo is anticipated to be high as the BGL increases. In the present study, we investigated the relationship between RBC aggregations by ultrasound and the BGL for the development of non-invasive BGL measurement methods. Ultrasonic backscattering echoes for dorsal hand vein and BGLs were repeatedly measured from fasting to 190 min after injecting 40-g glucose for a healthy subject. The brightness of the B-mode image increased as the BGL increased. The brightnesses of B-mode image and the BGLs after 160-190 min were less than those at fasting. The relationship between the brightness of the B-mode image and BGL was almost linear, although the hysteresis characteristic was observed. This is because multiple factors other than BGL are closely related to the RBC aggregations.
AB - High blood glucose level (BGL) is related to the high viscosity of blood. Red blood cells (RBCs) tend to gather each other in the condition of high viscosity. Backscattered echoes become high as RBCs aggregate. Therefore, the intensity of backscattered echo is anticipated to be high as the BGL increases. In the present study, we investigated the relationship between RBC aggregations by ultrasound and the BGL for the development of non-invasive BGL measurement methods. Ultrasonic backscattering echoes for dorsal hand vein and BGLs were repeatedly measured from fasting to 190 min after injecting 40-g glucose for a healthy subject. The brightness of the B-mode image increased as the BGL increased. The brightnesses of B-mode image and the BGLs after 160-190 min were less than those at fasting. The relationship between the brightness of the B-mode image and BGL was almost linear, although the hysteresis characteristic was observed. This is because multiple factors other than BGL are closely related to the RBC aggregations.
KW - aggregation
KW - blood glucose level
KW - red blood cell
KW - ultrasound scattering
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U2 - 10.1109/ULTSYM.2019.8926267
DO - 10.1109/ULTSYM.2019.8926267
M3 - Conference contribution
AN - SCOPUS:85077632305
T3 - IEEE International Ultrasonics Symposium, IUS
SP - 45
EP - 47
BT - 2019 IEEE International Ultrasonics Symposium, IUS 2019
PB - IEEE Computer Society
T2 - 2019 IEEE International Ultrasonics Symposium, IUS 2019
Y2 - 6 October 2019 through 9 October 2019
ER -