TY - JOUR
T1 - Correlation between human personality and neural activity in cerebral cortex
AU - Sugiura, Motoaki
AU - Kawashima, Ryuta
AU - Nakagawa, Manabu
AU - Okada, Ken
AU - Sato, Tachio
AU - Goto, Ryoi
AU - Sato, Kazunori
AU - Ono, Shuichi
AU - Schormann, Thorsten
AU - Zilles, Karl
AU - Fukuda, Hiroshi
N1 - Funding Information:
This work was supported by Grants-in-Aid for Scientific Research on Priority Research from the Japanese Ministry of Education, Science, Sports, and Culture (10164206, 09207102) and for Research for the Future from the Japan Society for the Promotion of Science (JSPS-RFTF 97L00202) and by the Telecommunications Advancement Organization of Japan. T. Schormann and K. Zilles were supported by a grant from the Deutsche Forschungsgemeinschaft (SFB194/A6). We thank N. Kijima at the National Institute of Vocational Rehabilitation, the Japan Association for Employment of the Disabled, and colleagues in the Department of Psychiatry, Tohoku University School of Medicine, for helpful advice on the usage of the Japanese short version of TCI, and M. Hosaka for cooperation in TCI data management.
PY - 2000/5
Y1 - 2000/5
N2 - Personality traits are a variance of behavioral patterns among individuals and may reflect a variance of brain activity, but their neurobiological explanation is still a matter of debate. Cloninger proposed three dimensions of personality traits, each of which has strong correlation with activity in a specific central monoaminergic system. Although this theory has been supported by physiological and genetic studies, it is still unclear how these personality parameters are correlated with the activity of the cortical networks which control human behavior. Here we measured the regional cerebral blood flow (rCBF) at rest in 30 normal volunteers who completed the personality inventory of Cloninger. Voxel-by-voxel analysis was employed to identify cortical regions where the rCBF showed significant correlation with any of the three personality parameters. Statistically significant correlation was observed in several paralimbic and neocortical regions and was consistent with the assumed monoaminergic influence on neural activity and the distribution of its projections, in each personality dimension. The results suggest that activity in a variety of cortical regions is associated with human personality traits and lend support to Cloninger's theory concerning central monoaminergic influence on human personality traits. (C) 2000 Academic Press.
AB - Personality traits are a variance of behavioral patterns among individuals and may reflect a variance of brain activity, but their neurobiological explanation is still a matter of debate. Cloninger proposed three dimensions of personality traits, each of which has strong correlation with activity in a specific central monoaminergic system. Although this theory has been supported by physiological and genetic studies, it is still unclear how these personality parameters are correlated with the activity of the cortical networks which control human behavior. Here we measured the regional cerebral blood flow (rCBF) at rest in 30 normal volunteers who completed the personality inventory of Cloninger. Voxel-by-voxel analysis was employed to identify cortical regions where the rCBF showed significant correlation with any of the three personality parameters. Statistically significant correlation was observed in several paralimbic and neocortical regions and was consistent with the assumed monoaminergic influence on neural activity and the distribution of its projections, in each personality dimension. The results suggest that activity in a variety of cortical regions is associated with human personality traits and lend support to Cloninger's theory concerning central monoaminergic influence on human personality traits. (C) 2000 Academic Press.
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U2 - 10.1006/nimg.2000.0564
DO - 10.1006/nimg.2000.0564
M3 - Article
C2 - 10806039
AN - SCOPUS:0034035703
VL - 11
SP - 541
EP - 546
JO - NeuroImage
JF - NeuroImage
SN - 1053-8119
IS - 5 I
ER -