TY - GEN
T1 - Correlated inhibitory firing and spike-timing-dependent plasticity
AU - Sakurai, Ichiro
AU - Kubota, Shigeru
AU - Niwano, Michio
PY - 2013
Y1 - 2013
N2 - Cortical inhibition by γ-aminobutyric acid (GABA) has been widely suggested to be required to trigger ocular dominance (OD) plasticity in the visual cortex. However, there is also evidence that only the circuits mediated by specific GABAA receptors can induce OD plasticity, which implies the importance of localized GABA circuits in this process. In this study, to investigate the role of local inhibition in visual plasticity, we simulated the synaptic dynamics regulated by lateral and backward inhibition. The lateral inhibition facilitated competitive interactions between different groups of excitatory correlated inputs, which were required to elicit experience-dependent synaptic modifications. Conversely, the backward inhibition suppressed such competitive interactions, which prevented synapses from reflecting past sensory experience. Our results suggest that the interactions between lateral and backward inhibition may regulate the timing and level of cortical plasticity by modulating the activity-dependent competitive function.
AB - Cortical inhibition by γ-aminobutyric acid (GABA) has been widely suggested to be required to trigger ocular dominance (OD) plasticity in the visual cortex. However, there is also evidence that only the circuits mediated by specific GABAA receptors can induce OD plasticity, which implies the importance of localized GABA circuits in this process. In this study, to investigate the role of local inhibition in visual plasticity, we simulated the synaptic dynamics regulated by lateral and backward inhibition. The lateral inhibition facilitated competitive interactions between different groups of excitatory correlated inputs, which were required to elicit experience-dependent synaptic modifications. Conversely, the backward inhibition suppressed such competitive interactions, which prevented synapses from reflecting past sensory experience. Our results suggest that the interactions between lateral and backward inhibition may regulate the timing and level of cortical plasticity by modulating the activity-dependent competitive function.
KW - Firing correlation
KW - Gaba inhibition
KW - STDP
KW - Synaptic competition
KW - Visual cortex
UR - http://www.scopus.com/inward/record.url?scp=84893386880&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84893386880&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-42054-2_21
DO - 10.1007/978-3-642-42054-2_21
M3 - Conference contribution
AN - SCOPUS:84893386880
SN - 9783642420535
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 161
EP - 167
BT - Neural Information Processing - 20th International Conference, ICONIP 2013, Proceedings
T2 - 20th International Conference on Neural Information Processing, ICONIP 2013
Y2 - 3 November 2013 through 7 November 2013
ER -