Correlated inhibitory firing and spike-timing-dependent plasticity

Ichiro Sakurai, Shigeru Kubota, Michio Niwano

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Cortical inhibition by γ-aminobutyric acid (GABA) has been widely suggested to be required to trigger ocular dominance (OD) plasticity in the visual cortex. However, there is also evidence that only the circuits mediated by specific GABAA receptors can induce OD plasticity, which implies the importance of localized GABA circuits in this process. In this study, to investigate the role of local inhibition in visual plasticity, we simulated the synaptic dynamics regulated by lateral and backward inhibition. The lateral inhibition facilitated competitive interactions between different groups of excitatory correlated inputs, which were required to elicit experience-dependent synaptic modifications. Conversely, the backward inhibition suppressed such competitive interactions, which prevented synapses from reflecting past sensory experience. Our results suggest that the interactions between lateral and backward inhibition may regulate the timing and level of cortical plasticity by modulating the activity-dependent competitive function.

Original languageEnglish
Title of host publicationNeural Information Processing - 20th International Conference, ICONIP 2013, Proceedings
Pages161-167
Number of pages7
EditionPART 1
DOIs
Publication statusPublished - 2013
Event20th International Conference on Neural Information Processing, ICONIP 2013 - Daegu, Korea, Republic of
Duration: 2013 Nov 32013 Nov 7

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
NumberPART 1
Volume8226 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other20th International Conference on Neural Information Processing, ICONIP 2013
CountryKorea, Republic of
CityDaegu
Period13/11/313/11/7

Keywords

  • Firing correlation
  • Gaba inhibition
  • STDP
  • Synaptic competition
  • Visual cortex

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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