Coronary artery spasm induced in atherosclerotic miniature swine

Hiroaki Shimokawa, Hitonobu Tomoike, Shozo Nabeyama, Hideo Yamamoto, Haruo Araki, Motoomi Nakamura, Yutaka Ishii, Kenzo Tanaka

Research output: Contribution to journalArticle

256 Citations (Scopus)

Abstract

Angiographically demonstrable coronary artery spasm could be provoked repeatedly by giving intracoronary or intravenous injections of histamine to miniature swine with experimentally induced atherosclerotic lesions of the coronary artery. The spasm induced in this way subsided either spontaneously or after the administration of nitroglycerin and was prevented by a calcium antagonist or an agent that blocks histamine H1 receptors. This model, which suggests that atherosclerotic changes may be one of the primary factors in the occurrence of coronary artery spasm, should facilitate studies on the pathogenesis of this condition.

Original languageEnglish
Pages (from-to)560-562
Number of pages3
JournalScience
Volume221
Issue number4610
DOIs
Publication statusPublished - 1983 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • General

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    Shimokawa, H., Tomoike, H., Nabeyama, S., Yamamoto, H., Araki, H., Nakamura, M., Ishii, Y., & Tanaka, K. (1983). Coronary artery spasm induced in atherosclerotic miniature swine. Science, 221(4610), 560-562. https://doi.org/10.1126/science.6408736