Cordybislactone, a stereoisomer of the 14-membered bislactone clonostachydiol, from the hopper pathogenic fungus Cordyceps sp. BCC 49294: Revision of the absolute configuration of clonostachydiol

Ken Ichi Ojima, Arunrat Yangchum, Pattiyaa Laksanacharoen, Kanoksri Tasanathai, Donnaya Thanakitpipattana, Hidetoshi Tokuyama, Masahiko Isaka

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Cordybislactone (3), a new stereoisomer of the 14-membered bislactone clonostachydiol, together with its open ring analog (4), was isolated from the hopper pathogenic fungus Cordyceps sp. BCC 49294. The relative and absolute configurations of 3 were determined by chemical derivatizations, including the modified Mosher's method. The stereochemistry of clonostachydiol was determined using the natural compound isolated from Xylaria sp. BCC 4297. The result revealed that the absolute configuration of clonostachydiol, previously determined by synthesis, should be revised to its enantiomer.

Original languageEnglish
Pages (from-to)351-358
Number of pages8
JournalJournal of Antibiotics
Volume71
Issue number3
DOIs
Publication statusPublished - 2018 Mar 1

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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