TY - JOUR
T1 - Cordybislactone, a stereoisomer of the 14-membered bislactone clonostachydiol, from the hopper pathogenic fungus Cordyceps sp. BCC 49294
T2 - Revision of the absolute configuration of clonostachydiol
AU - Ojima, Ken Ichi
AU - Yangchum, Arunrat
AU - Laksanacharoen, Pattiyaa
AU - Tasanathai, Kanoksri
AU - Thanakitpipattana, Donnaya
AU - Tokuyama, Hidetoshi
AU - Isaka, Masahiko
N1 - Funding Information:
Financial support from the Thailand Research Fund (Grant No. DBG5980002) and JSPS KAKENHI (Grant Numbers 16H01127, 16H00999, and a Grant-in-aid for Scientific Research (A) 26253001) is gratefully acknowledged. Ojima thanks JSPS KAKENHI, Grant-in-aid for Scientific Research Priority Area: Middle Molecular Strategy. We are grateful to Mr Prasert Srikitikulchai for identification of the fungus Xylaria sp. BCC 4297.
Funding Information:
Acknowledgements Financial support from the Thailand Research Fund (Grant No. DBG5980002) and JSPS KAKENHI (Grant Numbers 16H01127, 16H00999, and a Grant-in-aid for Scientific Research (A) 26253001) is gratefully acknowledged. Ojima thanks JSPS KAKENHI, Grant-in-aid for Scientific Research Priority Area: Middle Molecular Strategy. We are grateful to Mr Prasert Srikitikulchai for identification of the fungus Xylaria sp. BCC 4297.
Publisher Copyright:
© 2018 Japan Antibiotics Research Association.
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Cordybislactone (3), a new stereoisomer of the 14-membered bislactone clonostachydiol, together with its open ring analog (4), was isolated from the hopper pathogenic fungus Cordyceps sp. BCC 49294. The relative and absolute configurations of 3 were determined by chemical derivatizations, including the modified Mosher's method. The stereochemistry of clonostachydiol was determined using the natural compound isolated from Xylaria sp. BCC 4297. The result revealed that the absolute configuration of clonostachydiol, previously determined by synthesis, should be revised to its enantiomer.
AB - Cordybislactone (3), a new stereoisomer of the 14-membered bislactone clonostachydiol, together with its open ring analog (4), was isolated from the hopper pathogenic fungus Cordyceps sp. BCC 49294. The relative and absolute configurations of 3 were determined by chemical derivatizations, including the modified Mosher's method. The stereochemistry of clonostachydiol was determined using the natural compound isolated from Xylaria sp. BCC 4297. The result revealed that the absolute configuration of clonostachydiol, previously determined by synthesis, should be revised to its enantiomer.
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U2 - 10.1038/s41429-017-0008-9
DO - 10.1038/s41429-017-0008-9
M3 - Article
C2 - 29348525
AN - SCOPUS:85040648702
VL - 71
SP - 351
EP - 358
JO - Journal of Antibiotics
JF - Journal of Antibiotics
SN - 0021-8820
IS - 3
ER -