Copper-Catalyzed sp3 C-H Aminative Cyclization of 2-Alkyl-N-arylbenzamides: An Approach for the Synthesis of N-Aryl-isoindolinones

Kanako Nozawa-Kumada, Jun Kadokawa, Takehiro Kameyama, Yoshinori Kondo

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

The synthesis of isoindolinones via copper-catalyzed sp3 C-H functionalization of 2-alkyl-N-substituted benzamides is described. This process does not require the preparation of halogenated substitutes, expensive transition metals, or toxic Sn or CO gas. This method provides an efficient approach to generate various functionalized isoindolinones.

Original languageEnglish
Pages (from-to)4479-4481
Number of pages3
JournalOrganic letters
Volume17
Issue number18
DOIs
Publication statusPublished - 2015 Sep 18

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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