Copper-Catalyzed sp3 C-H Aminative Cyclization of 2-Alkyl-N-arylbenzamides: An Approach for the Synthesis of N-Aryl-isoindolinones

Kanako Nozawa-Kumada; Jun Kadokawa; Takehiro Kameyama; Yoshinori Kondo

doi:10.1021/acs.orglett.5b02235

Copper-Catalyzed sp³ C-H Aminative Cyclization of 2-Alkyl-N-arylbenzamides: An Approach for the Synthesis of N-Aryl-isoindolinones

Kanako Nozawa-Kumada, Jun Kadokawa, Takehiro Kameyama, Yoshinori Kondo

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

The synthesis of isoindolinones via copper-catalyzed sp³ C-H functionalization of 2-alkyl-N-substituted benzamides is described. This process does not require the preparation of halogenated substitutes, expensive transition metals, or toxic Sn or CO gas. This method provides an efficient approach to generate various functionalized isoindolinones.

Original language	English
Pages (from-to)	4479-4481
Number of pages	3
Journal	Organic letters
Volume	17
Issue number	18
DOIs	https://doi.org/10.1021/acs.orglett.5b02235
Publication status	Published - 2015 Sep 18

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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abstract = "The synthesis of isoindolinones via copper-catalyzed sp3 C-H functionalization of 2-alkyl-N-substituted benzamides is described. This process does not require the preparation of halogenated substitutes, expensive transition metals, or toxic Sn or CO gas. This method provides an efficient approach to generate various functionalized isoindolinones.",

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AU - Kameyama, Takehiro

AU - Kondo, Yoshinori

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N2 - The synthesis of isoindolinones via copper-catalyzed sp3 C-H functionalization of 2-alkyl-N-substituted benzamides is described. This process does not require the preparation of halogenated substitutes, expensive transition metals, or toxic Sn or CO gas. This method provides an efficient approach to generate various functionalized isoindolinones.

AB - The synthesis of isoindolinones via copper-catalyzed sp3 C-H functionalization of 2-alkyl-N-substituted benzamides is described. This process does not require the preparation of halogenated substitutes, expensive transition metals, or toxic Sn or CO gas. This method provides an efficient approach to generate various functionalized isoindolinones.

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