TY - JOUR
T1 - COPD uncovered
T2 - A cross-sectional study to assess the socioeconomic burden of COPD in Japan
AU - Igarashi, Ataru
AU - Fukuchi, Yoshinosuke
AU - Hirata, Kazuto
AU - Ichinose, Masakazu
AU - Nagai, Atsushi
AU - Nishimura, Masaharu
AU - Yoshisue, Hajime
AU - Ohara, Kenichi
AU - Gruenberger, Jean Bernard
N1 - Funding Information:
The authors received no compensation related to the development of the manuscript. AI reports fees from Novartis, Chugai Pharmaceuticals Inc., Astellas Pharma Inc., CSL Behring Japan Inc., Fuji file Inc., Takeda Pharmaceuticals Inc., Sanofi Japan Inc. and grants from Gilead Sciences K.K., AbbVie GK, Abbott Japan Inc., Beckton Dickinson and Company, Eli Lilly Japan K.K., Milliman Inc., Creativ-Ceuticals Inc., Pfizer Inc., Intuitive Surgical G.K. and Terumo corporation. YF reports fees from Novartis and Boehringer Ingelheim. KH reports fees from Novartis, Nippon Boehringer Ingelheim Co. Ltd., Chugai Pharmaceuticals Co. Ltd. and Astellas Pharma Inc. MI reports fees from Novartis, Boehringer Ingelheim and AstraZeneca. AN reports fees from Novartis, GlaxoSmithKline, Boehringer Ingelheim and AstraZen-eca. MN reports fees from Novartis, Nippon Boehringer Ingelheim, AstraZeneca and grants from Novartis Pharma K.K. HY, KO and JG are employees of study sponsor. The authors report no other conflicts of interest in this work.
Funding Information:
The authors would like to acknowledge all the investigators and their patients for commitment to this study. Authors would like to thank Vatsal Vithlani and Santanu Sannigrahi (professional medical writers; Novartis) for assistance in the preparation of this article in accordance with the third edition of Good Publication Practice guidelines. Medical writing support was funded by study sponsors. The authors also acknowledge IMS Health for conducting data analysis. This study was presented at the American Thoracic Society International Conference 2016, San Francisco, CA, USA, May 13–18, 2016 (Figures 1 and 3 and Tables 1–2 and 4), and the International Society for Pharmacoeconomics and Outcomes Research Asia-Pacific Conference 2016, Singapore, September 3–6, 2016 (Figures 1 and 2 and Tables 1–2). The study was funded by Novartis Pharma AG and Novartis Pharma K.K.
Publisher Copyright:
© 2018 Igarashi et al.
PY - 2018
Y1 - 2018
N2 - Background: COPD remains a major health problem in Japan. Patients with COPD experience a reduced quality of life (QoL) and have a higher chance of work impairment and productivity loss. However, there is a lack of data on the impact of COPD in terms of QoL and work activity impairment in Japan. This study assessed the socioeconomic burden of COPD in Japan and the impact it may have on the working age population. Patients and methods: This was a 2-year retrospective chart review in COPD patients aged ≥40 years, with at least one health care visit to clinic or hospital in the previous 12 months. Patients were required to have available medical charts for at least the previous 24 months. Symptoms were assessed using COPD assessment test score; EuroQoL Group 5 Dimension (EQ-5D-5L) and work productivity and activity impairment general health questionnaires were used to evaluate health-related QoL and work productivity, and health care resource utilization data were obtained from clinical charts. Results: In total, 71 patients aged <65 years, and 151 patients aged ≥65 years were included; the majority of patients had moderate or severe airflow limitation. Exacerbations (moderate or severe) were reported by ~35% of patients in both age groups; 52.1% and 62.9% of patients in the <65-year and ≥65-year age groups had COPD assessment test scores ≥10. EQ-5D-5L index scores in the <65-year and ≥65-year age groups were 0.79 and 0.77, respectively. Work productivity and activity impairment scores were higher in <65-year age group. Annual costs of health care resource use per patient in the <65-year and ≥65-year age groups were ¥438,975 (US$4,389) and ¥467,871 (US$4,678), respectively. Costs due to productivity loss were estimated to be ¥5,287,024 (US$52,870) in the <65-year age group and ¥3,018,974 (US$30,187) in the ≥65-year age group. Conclusion: COPD represents a significant socioeconomic burden in Japan. Patients with COPD report significant use of health care resources. Higher impact on work impairment and productivity loss was observed frequently in the working age population.
AB - Background: COPD remains a major health problem in Japan. Patients with COPD experience a reduced quality of life (QoL) and have a higher chance of work impairment and productivity loss. However, there is a lack of data on the impact of COPD in terms of QoL and work activity impairment in Japan. This study assessed the socioeconomic burden of COPD in Japan and the impact it may have on the working age population. Patients and methods: This was a 2-year retrospective chart review in COPD patients aged ≥40 years, with at least one health care visit to clinic or hospital in the previous 12 months. Patients were required to have available medical charts for at least the previous 24 months. Symptoms were assessed using COPD assessment test score; EuroQoL Group 5 Dimension (EQ-5D-5L) and work productivity and activity impairment general health questionnaires were used to evaluate health-related QoL and work productivity, and health care resource utilization data were obtained from clinical charts. Results: In total, 71 patients aged <65 years, and 151 patients aged ≥65 years were included; the majority of patients had moderate or severe airflow limitation. Exacerbations (moderate or severe) were reported by ~35% of patients in both age groups; 52.1% and 62.9% of patients in the <65-year and ≥65-year age groups had COPD assessment test scores ≥10. EQ-5D-5L index scores in the <65-year and ≥65-year age groups were 0.79 and 0.77, respectively. Work productivity and activity impairment scores were higher in <65-year age group. Annual costs of health care resource use per patient in the <65-year and ≥65-year age groups were ¥438,975 (US$4,389) and ¥467,871 (US$4,678), respectively. Costs due to productivity loss were estimated to be ¥5,287,024 (US$52,870) in the <65-year age group and ¥3,018,974 (US$30,187) in the ≥65-year age group. Conclusion: COPD represents a significant socioeconomic burden in Japan. Patients with COPD report significant use of health care resources. Higher impact on work impairment and productivity loss was observed frequently in the working age population.
KW - Chart review
KW - EQ-5D-5L questionnaire
KW - Health care resource utilization
KW - Health-realted quality of life
KW - Productivity loss
KW - Work impairment WPAI-GH
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U2 - 10.2147/COPD.S167476
DO - 10.2147/COPD.S167476
M3 - Article
C2 - 30214181
AN - SCOPUS:85058472686
VL - 13
SP - 2629
EP - 2641
JO - International Journal of COPD
JF - International Journal of COPD
SN - 1176-9106
ER -
