Cooperative regulation of the host defense to cryptococcal infection by innate immune lymphocytes

Takeshi Kinjo, Jiro Fujita, Kazuyoshi Kawakami

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

Cryptococcus neoformans is an opportunistic fungal infectious pathogen in immunocompromised patients with acquired immunodeficiency syndrome and hematological malignancies. Recently, innate immune cells, such as NK, NKT and γδ T cells, have been found critical for determining the quality of acquired immunity by affecting the direction of Th1-Th2 balance. Th1-type immune response is important for the host defense against C. neoformans, and innate immunity may involve this process. In the present review, the accumulated knowledge including our own data on the role of innate immune lymphocytes in the host defense to this fungal pathogen are summarized, focusing on NKT and γδ T cells.

Original languageEnglish
Pages (from-to)201-207
Number of pages7
JournalJapanese Journal of Medical Mycology
Volume47
Issue number3
DOIs
Publication statusPublished - 2006

Keywords

  • Antifungal immunity
  • Cryptococcus neoformans
  • Innate immunity
  • NKT (NKT cells)
  • γδ T cells

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

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