Conversion of prelaureatin into laurallene, a bromo-allene compound, by enzymatic and chemical bromo-etherification reactions

Jun Ishihara, Yoshikatsu Shimada, Naoki Kanoh, Yasunori Takasugi, Akio Fukuzawa, Akio Murai

Research output: Contribution to journalArticlepeer-review

58 Citations (Scopus)

Abstract

Studies on biomimetic conversion of prelaureatin into laurallene were reported. This unique bromo-allene compound has been assumed to be biogenetically synthesized by bromo-cationic reaction of prelaureatin, an eight-membered ether, containing an enyne unit. The electrophilic bromination afforded laurallenic chemically and enzymatically.

Original languageEnglish
Pages (from-to)8371-8382
Number of pages12
JournalTetrahedron
Volume53
Issue number25
DOIs
Publication statusPublished - 1997 Jun 23

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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