Convergent synthesis of an HIJK ring model of ciguatoxin via Suzuki cross-coupling reaction

Makoto Sasaki, Katsuhiko Noguchi, Haruhiko Fuwa, Kazuo Tachibana

    Research output: Contribution to journalArticle

    53 Citations (Scopus)

    Abstract

    Convergent synthesis of HIJK ring model compound 1 of ciguatoxin is described. The present synthesis relied on a palladium-catalyzed Suzuki cross-coupling reaction between eight-membered ketene acetal phosphate 2 and seven-membered alkylborane 6. (C) 2000 Elsevier Science Ltd.

    Original languageEnglish
    Pages (from-to)1425-1428
    Number of pages4
    JournalTetrahedron Letters
    Volume41
    Issue number9
    DOIs
    Publication statusPublished - 2000 Feb 26

    Keywords

    • Coupling reactions
    • Polyethers
    • Suzuki reactions
    • Toxins

    ASJC Scopus subject areas

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry

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