Convergent synthesis of 2-aryl-substituted quinolines by gold-catalyzed cascade reaction

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Gold-catalyzed auto-tandem catalysis has been developed for synthesizing 2-aryl-substituted quinolines. The reaction of an aniline bearing an acetal moiety with an aryl alkyne proceeded via formal [4+2]-cycloaddition, which involved the addition of gold acetylide to an oxonium ion to give amino alkyne intermediate and sequential 6-endo-dig cyclization of amino alkyne intermediate by attacking of nitrogen to alkyne moiety activated by gold catalyst. The cationic gold catalyst promoted two different processes by enhancing the nucleophilicity and electrophilicity of alkyne. This convergent synthetic methodology enabled the synthesis of a variety of 2-aryl-substituted quinolines.

Original languageEnglish
Pages (from-to)824-829
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Issue number7
Publication statusPublished - 2016


  • Cyclization
  • Gold catalysis
  • Heterocyclic compound
  • Quinoline
  • Tandem reaction

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery


Dive into the research topics of 'Convergent synthesis of 2-aryl-substituted quinolines by gold-catalyzed cascade reaction'. Together they form a unique fingerprint.

Cite this