Convergent synthesis and biological activity of the WXYZA′B′ C′ ring system of maitotoxin

Tohru Oishi; Futoshi Hasegawa; Kohei Torikai; Keiichi Konoki; Nobuaki Matsumori; Michio Murata

doi:10.1021/ol801369g

Convergent synthesis and biological activity of the WXYZA′B′ C′ ring system of maitotoxin

Tohru Oishi, Futoshi Hasegawa, Kohei Torikai, Keiichi Konoki, Nobuaki Matsumori, Michio Murata

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

(Chemical Equation Presented) The WXYZA′B′C′ ring system (1) of maitotoxin (MTX) was synthesized in a convergent manner via successive coupling of the W, Z, and C′ ring fragments through construction of the XY and A′B′ ring systems. The synthetic segment 1 blocked the hemolytic activity elicited by MTX.

Original language	English
Pages (from-to)	3599-3602
Number of pages	4
Journal	Organic letters
Volume	10
Issue number	16
DOIs	https://doi.org/10.1021/ol801369g
Publication status	Published - 2008 Dec 1
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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abstract = "(Chemical Equation Presented) The WXYZA′B′C′ ring system (1) of maitotoxin (MTX) was synthesized in a convergent manner via successive coupling of the W, Z, and C′ ring fragments through construction of the XY and A′B′ ring systems. The synthetic segment 1 blocked the hemolytic activity elicited by MTX.",

author = "Tohru Oishi and Futoshi Hasegawa and Kohei Torikai and Keiichi Konoki and Nobuaki Matsumori and Michio Murata",

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AU - Konoki, Keiichi

AU - Matsumori, Nobuaki

AU - Murata, Michio

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