Convergent assembly of the spiroacetal subunit of didemnaketal B

Haruhiko Fuwa, Sayaka Noji, Makoto Sasaki

    Research output: Contribution to journalArticlepeer-review

    21 Citations (Scopus)

    Abstract

    A highly convergent synthesis of the C9-C28 spiroacetal subunit of didemnaketal B has been accomplished. Assembly of the C9-C15 alkylborate and C16-C21 enol phosphate by means of Suzuki-Miyaura coupling and acid-catalyzed cyclization of the derived dihydroxy enol ether enabled a rapid and efficient construction of the spiroacetal subunit. The C22-C28 side chain was incorporated via Nozaki-Hiyama-Kishi coupling to complete the synthesis.

    Original languageEnglish
    Pages (from-to)5354-5357
    Number of pages4
    JournalOrganic letters
    Volume12
    Issue number22
    DOIs
    Publication statusPublished - 2010 Nov 19

    ASJC Scopus subject areas

    • Biochemistry
    • Physical and Theoretical Chemistry
    • Organic Chemistry

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