Convenient synthesis of triarylamines via ester-mediated nucleophilic aromatic substitution

Tetsutaro Hattori, Takashi Satoh, Sotaro Miyano

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

A convenient method for the preparation of arylamines via nucleophilic displacement of methoxy- and/or fluorobenzoates with lithium amides is presented. Treatment of 2,6-di-tert-butyl-4-methoxyphenyl 2- or 4-fluorobenzoate (2 or 7) with lithium diarylamides 3e-h in THF and/or THF/HMPA under mild conditions affords the 2- or 4-(diarylamino)benzoates 4e-h or 8g, h in good to excellent yields.

Original languageEnglish
Pages (from-to)514-518
Number of pages5
JournalSynthesis
Issue number4
Publication statusPublished - 1996 Jan 1

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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