Abstract
The cyclization reaction of various 2-ethynylanilines, which were easily synthesized from 2-haloanilines by the palladium-catalyzed reaction with terminal alkynes, with tetrabutylammonium fluoride (TBAF) to yield 2-substituted indoles proceeded at refluxing or room temperature in THF in excellent yields without affecting the bromo, chloro, cyano, ethoxycarbonyl, and ethynyl groups.
| Original language | English |
|---|---|
| Pages (from-to) | 529-534 |
| Number of pages | 6 |
| Journal | Journal of the Chemical Society - Perkin Transactions 1 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1999 Jan 1 |
ASJC Scopus subject areas
- Chemistry(all)
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Cite this
Yasuhara, A., Kanamori, Y., Kancko, M., Numata, A., Kondo, Y., & Sakamoto, T. (1999). Convenient synthesis of 2-substituted indoles from 2-ethynylanilines with tetrabutylammonium fluoride. Journal of the Chemical Society - Perkin Transactions 1, (4), 529-534. https://doi.org/10.1039/a808842j