Convenient synthesis of 2-substituted indoles from 2-ethynylanilines with tetrabutylammonium fluoride

Akito Yasuhara, Yuichi Kanamori, Masashi Kancko, Atsushi Numata, Yoshinori Kondo, Takao Sakamoto

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

The cyclization reaction of various 2-ethynylanilines, which were easily synthesized from 2-haloanilines by the palladium-catalyzed reaction with terminal alkynes, with tetrabutylammonium fluoride (TBAF) to yield 2-substituted indoles proceeded at refluxing or room temperature in THF in excellent yields without affecting the bromo, chloro, cyano, ethoxycarbonyl, and ethynyl groups.

Original languageEnglish
Pages (from-to)529-534
Number of pages6
JournalJournal of the Chemical Society - Perkin Transactions 1
Issue number4
DOIs
Publication statusPublished - 1999 Jan 1

ASJC Scopus subject areas

  • Chemistry(all)

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